node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LUC7L | LUC7L2 | ENSP00000293872 | ENSP00000347005 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | 0.935 |
LUC7L | SCNM1 | ENSP00000293872 | ENSP00000357901 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Sodium channel modifier 1; Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites. | 0.431 |
LUC7L | SNRNP70 | ENSP00000293872 | ENSP00000472998 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. | 0.994 |
LUC7L | SNRPC | ENSP00000293872 | ENSP00000244520 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] | 0.988 |
LUC7L | SNRPD1 | ENSP00000293872 | ENSP00000300413 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with R [...] | 0.966 |
LUC7L | SNRPD2 | ENSP00000293872 | ENSP00000342374 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. | 0.960 |
LUC7L | SNRPD3 | ENSP00000293872 | ENSP00000215829 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity). | 0.936 |
LUC7L | SNRPE | ENSP00000293872 | ENSP00000400591 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. | 0.922 |
LUC7L | SNRPF | ENSP00000293872 | ENSP00000266735 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Small nuclear ribonucleoprotein F; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. | 0.920 |
LUC7L | U2AF2 | ENSP00000293872 | ENSP00000307863 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | Splicing factor U2AF 65 kDa subunit; Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucl [...] | 0.889 |
LUC7L2 | LUC7L | ENSP00000347005 | ENSP00000293872 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain. | 0.935 |
LUC7L2 | SCNM1 | ENSP00000347005 | ENSP00000357901 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | Sodium channel modifier 1; Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites. | 0.926 |
LUC7L2 | SNRNP70 | ENSP00000347005 | ENSP00000472998 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. | 0.984 |
LUC7L2 | SNRPC | ENSP00000347005 | ENSP00000244520 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] | 0.958 |
LUC7L2 | SNRPD1 | ENSP00000347005 | ENSP00000300413 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with R [...] | 0.952 |
LUC7L2 | SNRPD2 | ENSP00000347005 | ENSP00000342374 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. | 0.985 |
LUC7L2 | SNRPD3 | ENSP00000347005 | ENSP00000215829 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity). | 0.913 |
LUC7L2 | SNRPE | ENSP00000347005 | ENSP00000400591 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. | 0.949 |
LUC7L2 | SNRPF | ENSP00000347005 | ENSP00000266735 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | Small nuclear ribonucleoprotein F; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. | 0.910 |
LUC7L2 | U2AF2 | ENSP00000347005 | ENSP00000307863 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain. | Splicing factor U2AF 65 kDa subunit; Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucl [...] | 0.944 |