node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DMRTC2 | LYPD4 | ENSP00000269945 | ENSP00000476510 | Doublesex- and mab-3-related transcription factor C2; May be involved in sexual development. | LY6/PLAUR domain containing 4. | 0.629 |
LY6H | LY6K | ENSP00000399485 | ENSP00000292430 | Lymphocyte antigen 6H; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4- containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. | Lymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth. | 0.738 |
LY6H | LYPD2 | ENSP00000399485 | ENSP00000352163 | Lymphocyte antigen 6H; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4- containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. | LY6/PLAUR domain containing 2. | 0.715 |
LY6H | LYPD4 | ENSP00000399485 | ENSP00000476510 | Lymphocyte antigen 6H; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4- containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. | LY6/PLAUR domain containing 4. | 0.645 |
LY6H | PATE2 | ENSP00000399485 | ENSP00000351325 | Lymphocyte antigen 6H; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4- containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. | Prostate and testis expressed 2. | 0.570 |
LY6H | PATE3 | ENSP00000399485 | ENSP00000395505 | Lymphocyte antigen 6H; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4- containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. | Prostate and testis expressed 3; Belongs to the PATE family. | 0.593 |
LY6H | PATE4 | ENSP00000399485 | ENSP00000411439 | Lymphocyte antigen 6H; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4- containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. | Prostate and testis expressed protein 4; May modulate the function of nicotinic acetylcholine receptors. May enhance sperm motility. | 0.544 |
LY6H | PINLYP | ENSP00000399485 | ENSP00000479240 | Lymphocyte antigen 6H; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4- containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. | Phospholipase A2 inhibitor and LY6/PLAUR domain containing; Belongs to the CNF-like-inhibitor family. | 0.543 |
LY6H | SPACA4 | ENSP00000399485 | ENSP00000312774 | Lymphocyte antigen 6H; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4- containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. | Sperm acrosome membrane-associated protein 4; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. | 0.547 |
LY6K | LY6H | ENSP00000292430 | ENSP00000399485 | Lymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth. | Lymphocyte antigen 6H; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4- containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. | 0.738 |
LY6K | LY6L | ENSP00000292430 | ENSP00000455811 | Lymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth. | Lymphocyte antigen 6 family member L. | 0.522 |
LY6K | LYPD2 | ENSP00000292430 | ENSP00000352163 | Lymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth. | LY6/PLAUR domain containing 2. | 0.794 |
LY6K | LYPD4 | ENSP00000292430 | ENSP00000476510 | Lymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth. | LY6/PLAUR domain containing 4. | 0.592 |
LY6K | PATE2 | ENSP00000292430 | ENSP00000351325 | Lymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth. | Prostate and testis expressed 2. | 0.447 |
LY6K | PATE3 | ENSP00000292430 | ENSP00000395505 | Lymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth. | Prostate and testis expressed 3; Belongs to the PATE family. | 0.507 |
LY6K | PATE4 | ENSP00000292430 | ENSP00000411439 | Lymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth. | Prostate and testis expressed protein 4; May modulate the function of nicotinic acetylcholine receptors. May enhance sperm motility. | 0.447 |
LY6K | PINLYP | ENSP00000292430 | ENSP00000479240 | Lymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth. | Phospholipase A2 inhibitor and LY6/PLAUR domain containing; Belongs to the CNF-like-inhibitor family. | 0.418 |
LY6K | SPACA4 | ENSP00000292430 | ENSP00000312774 | Lymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth. | Sperm acrosome membrane-associated protein 4; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. | 0.573 |
LY6L | LY6K | ENSP00000455811 | ENSP00000292430 | Lymphocyte antigen 6 family member L. | Lymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth. | 0.522 |
LY6L | LYPD2 | ENSP00000455811 | ENSP00000352163 | Lymphocyte antigen 6 family member L. | LY6/PLAUR domain containing 2. | 0.593 |