node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASTL | LYZL4 | ENSP00000343674 | ENSP00000287748 | Astacin-like metalloendopeptidase; Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity). | Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family. | 0.453 |
C12orf71 | LYZL4 | ENSP00000413728 | ENSP00000287748 | Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71. | Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family. | 0.518 |
C12orf71 | SPRYD4 | ENSP00000413728 | ENSP00000338034 | Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71. | SPRY domain containing 4. | 0.527 |
C12orf71 | YEATS4 | ENSP00000413728 | ENSP00000247843 | Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71. | YEATS domain-containing protein 4; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and repl [...] | 0.532 |
C1orf115 | LYZL4 | ENSP00000294889 | ENSP00000287748 | Uncharacterized protein C1orf115; Chromosome 1 open reading frame 115. | Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family. | 0.481 |
C1orf115 | RASGEF1C | ENSP00000294889 | ENSP00000377037 | Uncharacterized protein C1orf115; Chromosome 1 open reading frame 115. | Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF). | 0.488 |
C1orf115 | TMEM244 | ENSP00000294889 | ENSP00000357125 | Uncharacterized protein C1orf115; Chromosome 1 open reading frame 115. | Transmembrane protein 244. | 0.528 |
DUSP13 | LYZL4 | ENSP00000475626 | ENSP00000287748 | Dual specificity protein phosphatase 13 isoform B; Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro. | Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family. | 0.404 |
LYZL4 | ASTL | ENSP00000287748 | ENSP00000343674 | Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family. | Astacin-like metalloendopeptidase; Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity). | 0.453 |
LYZL4 | C12orf71 | ENSP00000287748 | ENSP00000413728 | Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family. | Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71. | 0.518 |
LYZL4 | C1orf115 | ENSP00000287748 | ENSP00000294889 | Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family. | Uncharacterized protein C1orf115; Chromosome 1 open reading frame 115. | 0.481 |
LYZL4 | DUSP13 | ENSP00000287748 | ENSP00000475626 | Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family. | Dual specificity protein phosphatase 13 isoform B; Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro. | 0.404 |
LYZL4 | OR51D1 | ENSP00000287748 | ENSP00000492986 | Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family. | Olfactory receptor 51D1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.432 |
LYZL4 | RASGEF1C | ENSP00000287748 | ENSP00000377037 | Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family. | Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF). | 0.477 |
LYZL4 | SPRYD4 | ENSP00000287748 | ENSP00000338034 | Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family. | SPRY domain containing 4. | 0.432 |
LYZL4 | TEX38 | ENSP00000287748 | ENSP00000455854 | Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family. | Testis-expressed protein 38; Testis expressed 38. | 0.404 |
LYZL4 | TMEM244 | ENSP00000287748 | ENSP00000357125 | Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family. | Transmembrane protein 244. | 0.511 |
LYZL4 | YEATS4 | ENSP00000287748 | ENSP00000247843 | Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family. | YEATS domain-containing protein 4; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and repl [...] | 0.460 |
OR51D1 | LYZL4 | ENSP00000492986 | ENSP00000287748 | Olfactory receptor 51D1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family. | 0.432 |
OR51D1 | TEX38 | ENSP00000492986 | ENSP00000455854 | Olfactory receptor 51D1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Testis-expressed protein 38; Testis expressed 38. | 0.530 |