node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD66 | ANKUB1 | ENSP00000454770 | ENSP00000417635 | Ankyrin repeat domain 66. | Protein ANKUB1; Ankyrin repeat and ubiquitin domain containing 1. | 0.545 |
ANKRD66 | C11orf88 | ENSP00000454770 | ENSP00000333845 | Ankyrin repeat domain 66. | UPF0722 protein C11orf88. | 0.544 |
ANKRD66 | FAM216B | ENSP00000454770 | ENSP00000445786 | Ankyrin repeat domain 66. | Protein FAM216B; Family with sequence similarity 216 member B; Belongs to the FAM216 family. | 0.491 |
ANKRD66 | MAP3K19 | ENSP00000454770 | ENSP00000376647 | Ankyrin repeat domain 66. | Mitogen-activated protein kinase kinase kinase 19. | 0.489 |
ANKUB1 | ANKRD66 | ENSP00000417635 | ENSP00000454770 | Protein ANKUB1; Ankyrin repeat and ubiquitin domain containing 1. | Ankyrin repeat domain 66. | 0.545 |
ANKUB1 | C11orf88 | ENSP00000417635 | ENSP00000333845 | Protein ANKUB1; Ankyrin repeat and ubiquitin domain containing 1. | UPF0722 protein C11orf88. | 0.521 |
ANKUB1 | FAM216B | ENSP00000417635 | ENSP00000445786 | Protein ANKUB1; Ankyrin repeat and ubiquitin domain containing 1. | Protein FAM216B; Family with sequence similarity 216 member B; Belongs to the FAM216 family. | 0.576 |
ANKUB1 | MAP3K19 | ENSP00000417635 | ENSP00000376647 | Protein ANKUB1; Ankyrin repeat and ubiquitin domain containing 1. | Mitogen-activated protein kinase kinase kinase 19. | 0.526 |
C11orf88 | ANKRD66 | ENSP00000333845 | ENSP00000454770 | UPF0722 protein C11orf88. | Ankyrin repeat domain 66. | 0.544 |
C11orf88 | ANKUB1 | ENSP00000333845 | ENSP00000417635 | UPF0722 protein C11orf88. | Protein ANKUB1; Ankyrin repeat and ubiquitin domain containing 1. | 0.521 |
C11orf88 | FAM216B | ENSP00000333845 | ENSP00000445786 | UPF0722 protein C11orf88. | Protein FAM216B; Family with sequence similarity 216 member B; Belongs to the FAM216 family. | 0.669 |
C11orf88 | MAP3K19 | ENSP00000333845 | ENSP00000376647 | UPF0722 protein C11orf88. | Mitogen-activated protein kinase kinase kinase 19. | 0.580 |
DYRK1B | MAP3K19 | ENSP00000469863 | ENSP00000376647 | Dual specificity tyrosine-phosphorylation-regulated kinase 1B; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. | Mitogen-activated protein kinase kinase kinase 19. | 0.531 |
FAM216B | ANKRD66 | ENSP00000445786 | ENSP00000454770 | Protein FAM216B; Family with sequence similarity 216 member B; Belongs to the FAM216 family. | Ankyrin repeat domain 66. | 0.491 |
FAM216B | ANKUB1 | ENSP00000445786 | ENSP00000417635 | Protein FAM216B; Family with sequence similarity 216 member B; Belongs to the FAM216 family. | Protein ANKUB1; Ankyrin repeat and ubiquitin domain containing 1. | 0.576 |
FAM216B | C11orf88 | ENSP00000445786 | ENSP00000333845 | Protein FAM216B; Family with sequence similarity 216 member B; Belongs to the FAM216 family. | UPF0722 protein C11orf88. | 0.669 |
FAM216B | MAP3K19 | ENSP00000445786 | ENSP00000376647 | Protein FAM216B; Family with sequence similarity 216 member B; Belongs to the FAM216 family. | Mitogen-activated protein kinase kinase kinase 19. | 0.498 |
KRBA2 | MAP3K19 | ENSP00000494883 | ENSP00000376647 | KRAB-A domain containing 2. | Mitogen-activated protein kinase kinase kinase 19. | 0.515 |
MAP2K1 | MAP2K2 | ENSP00000302486 | ENSP00000262948 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] | Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation. | 0.996 |
MAP2K1 | MAP3K19 | ENSP00000302486 | ENSP00000376647 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] | Mitogen-activated protein kinase kinase kinase 19. | 0.478 |