STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MFSD12Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain containing 12 (480 aa)    
Predicted Functional Partners:
FZR1
Fizzy-related protein homolog; Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and [...]
   
  
 0.908
TMEM138
Transmembrane protein 138; Required for ciliogenesis
   
  
 0.760
TMEM180
Major facilitator superfamily domain containing 13a; Transmembrane protein 180
      
 0.731
TBC1D16
TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s)
   
  
 0.723
BEND7
Ben domain-containing protein 7; BEN domain containing 7
      
 0.702
ALX3
Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes
   
  
 0.696
MFSD9
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain containing 9
      
 0.679
MFSD10
Major facilitator superfamily domain-containing protein 10; Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump
   
  
 0.670
MFSD6L
Major facilitator superfamily domain-containing protein 6-like; Major facilitator superfamily domain containing 6 like
   
  
 0.667
MFSD11
UNC93-like protein MFSD11; Major facilitator superfamily domain containing 11; Belongs to the unc-93 family
      
 0.666
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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