MFSD8 protein (human) - STRING interaction network

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Score

MFSD8

Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients. (518 aa)

Predicted Functional Partners:

CLN8

0.963

CLN3

0.952

CLN6

0.947

CLN5

0.938

PPT1

0.915

DNAJC5

0.838

CTSD

0.789

KCTD7

0.776

CTSF

0.708

TPP1

0.687

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLN3	CLN5	ENSP00000454229	ENSP00000498772	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	0.997
CLN3	CLN6	ENSP00000454229	ENSP00000249806	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	CLN6 transmembrane ER protein.	0.979
CLN3	CLN8	ENSP00000454229	ENSP00000328182	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.	0.966
CLN3	CTSD	ENSP00000454229	ENSP00000236671	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.	0.837
CLN3	CTSF	ENSP00000454229	ENSP00000310832	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.	0.676
CLN3	DNAJC5	ENSP00000454229	ENSP00000354111	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	DnaJ homolog subfamily C member 5; Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).	0.914
CLN3	KCTD7	ENSP00000454229	ENSP00000492240	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	BTB/POZ domain-containing protein KCTD7; May be involved in the control of excitability of cortical neurons.	0.728
CLN3	MFSD8	ENSP00000454229	ENSP00000493218	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients.	0.952
CLN3	PPT1	ENSP00000454229	ENSP00000493153	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons ; Belongs to the palmitoyl-protein thioesterase family.	0.985
CLN3	TPP1	ENSP00000454229	ENSP00000299427	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus.	0.911
CLN5	CLN3	ENSP00000498772	ENSP00000454229	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.	0.997
CLN5	CLN6	ENSP00000498772	ENSP00000249806	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	CLN6 transmembrane ER protein.	0.987
CLN5	CLN8	ENSP00000498772	ENSP00000328182	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.	0.978
CLN5	CTSD	ENSP00000498772	ENSP00000236671	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.	0.803
CLN5	CTSF	ENSP00000498772	ENSP00000310832	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	Cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.	0.696
CLN5	DNAJC5	ENSP00000498772	ENSP00000354111	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	DnaJ homolog subfamily C member 5; Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).	0.837
CLN5	KCTD7	ENSP00000498772	ENSP00000492240	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	BTB/POZ domain-containing protein KCTD7; May be involved in the control of excitability of cortical neurons.	0.790
CLN5	MFSD8	ENSP00000498772	ENSP00000493218	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients.	0.938
CLN5	PPT1	ENSP00000498772	ENSP00000493153	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons ; Belongs to the palmitoyl-protein thioesterase family.	0.978
CLN5	TPP1	ENSP00000498772	ENSP00000299427	Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.	Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus.	0.769