STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MMGT1Membrane magnesium transporter 1; Mediates Mg(2+) transport; Belongs to the membrane magnesium transporter (TC 1.A.67) family (131 aa)    
Predicted Functional Partners:
EMC6
ER membrane protein complex subunit 6; Belongs to the EMC6 family
   
 0.996
EMC9
ER membrane protein complex subunit 9
   
 0.996
EMC7
ER membrane protein complex subunit 7
   
 0.995
EMC4
ER membrane protein complex subunit 4; May mediate anti-apoptotic activity
   
 0.995
EMC3
ER membrane protein complex subunit 3
   
 0.994
EMC10
ER membrane protein complex subunit 10; Belongs to the EMC10 family
   
 0.994
EMC1
ER membrane protein complex subunit 1; Belongs to the EMC1 family
   
 0.994
EMC2
ER membrane protein complex subunit 2; Tetratricopeptide repeat domain containing
   
 0.993
EMC8
ER membrane protein complex subunit 8
   
 0.992
UBQLN2
Ubiquilin-2; Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and the endoplasmic reticulum- associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form [...]
   
 
 0.888
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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