node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CETN1 | CETN2 | ENSP00000319052 | ENSP00000359300 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function. Plays a role in sperm cilia formation (By similarity). | Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA hel [...] | 0.741 |
CETN1 | MORN1 | ENSP00000319052 | ENSP00000367792 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function. Plays a role in sperm cilia formation (By similarity). | MORN repeat containing 1. | 0.696 |
CETN2 | CETN1 | ENSP00000359300 | ENSP00000319052 | Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA hel [...] | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function. Plays a role in sperm cilia formation (By similarity). | 0.741 |
CETN2 | MORN1 | ENSP00000359300 | ENSP00000367792 | Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA hel [...] | MORN repeat containing 1. | 0.706 |
CETN2 | TBCCD1 | ENSP00000359300 | ENSP00000411253 | Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA hel [...] | TBCC domain-containing protein 1; Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration. | 0.536 |
DHFR | MORN1 | ENSP00000396308 | ENSP00000367792 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. | MORN repeat containing 1. | 0.455 |
IQCC | MORN1 | ENSP00000442291 | ENSP00000367792 | IQ motif containing C. | MORN repeat containing 1. | 0.533 |
JPH4 | MORN1 | ENSP00000380307 | ENSP00000367792 | Junctophilin-4; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity). | MORN repeat containing 1. | 0.515 |
MEGF6 | MORN1 | ENSP00000348982 | ENSP00000367792 | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6. | MORN repeat containing 1. | 0.462 |
MEGF6 | ZNF251 | ENSP00000348982 | ENSP00000292562 | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6. | Zinc finger protein 251; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.462 |
MORN1 | CETN1 | ENSP00000367792 | ENSP00000319052 | MORN repeat containing 1. | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function. Plays a role in sperm cilia formation (By similarity). | 0.696 |
MORN1 | CETN2 | ENSP00000367792 | ENSP00000359300 | MORN repeat containing 1. | Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA hel [...] | 0.706 |
MORN1 | DHFR | ENSP00000367792 | ENSP00000396308 | MORN repeat containing 1. | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. | 0.455 |
MORN1 | IQCC | ENSP00000367792 | ENSP00000442291 | MORN repeat containing 1. | IQ motif containing C. | 0.533 |
MORN1 | JPH4 | ENSP00000367792 | ENSP00000380307 | MORN repeat containing 1. | Junctophilin-4; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity). | 0.515 |
MORN1 | MEGF6 | ENSP00000367792 | ENSP00000348982 | MORN repeat containing 1. | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6. | 0.462 |
MORN1 | MORN5 | ENSP00000367792 | ENSP00000362869 | MORN repeat containing 1. | MORN repeat containing 5. | 0.534 |
MORN1 | TBCCD1 | ENSP00000367792 | ENSP00000411253 | MORN repeat containing 1. | TBCC domain-containing protein 1; Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration. | 0.591 |
MORN1 | WAC | ENSP00000367792 | ENSP00000346986 | MORN repeat containing 1. | WW domain-containing adapter protein with coiled-coil; Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates MTOR activity by promot [...] | 0.462 |
MORN1 | ZNF251 | ENSP00000367792 | ENSP00000292562 | MORN repeat containing 1. | Zinc finger protein 251; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.503 |