STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MRM3rRNA methyltransferase 3, mitochondrial; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA. (420 aa)    
Predicted Functional Partners:
MALSU1
Mitochondrial assembly of ribosomal large subunit protein 1; Required for normal mitochondrial ribosome function and mitochondrial translation. May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable). Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits (Probable). Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of [...]
  
 
 0.997
MRPL47
Mitochondrial ribosomal protein L47; Belongs to the universal ribosomal protein uL29 family.
   
 
 0.991
DDX28
Probable ATP-dependent RNA helicase DDX28; Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. May be involved in RNA processing or transport. Has RNA and Mg(2+)- dependent ATPase activity.
  
 
 0.990
MRPL13
Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family.
  
 
 0.981
MRPL11
Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family.
  
 
 0.979
MRPL17
Mitochondrial ribosomal protein L17.
  
 
 0.978
MRPL3
Mitochondrial ribosomal protein L3.
  
 
 0.977
MRPL21
Mitochondrial ribosomal protein L21.
  
   0.975
MRPL24
Mitochondrial ribosomal protein L24; Belongs to the universal ribosomal protein uL24 family.
  
 
 0.974
MRPL43
Mitochondrial ribosomal protein L43.
   
   0.972
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.