MRPL57 protein (human) - STRING interaction network

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Score

MRPL57

Mitochondrial ribosomal protein L57; Belongs to the mitochondrion-specific ribosomal protein mL63 family. (102 aa)

Predicted Functional Partners:

MRPL50

0.984

MRPL4

0.979

MRPL52

0.977

GADD45GIP1

0.972

MRPL47

0.969

MRPL10

0.968

MRPL39

0.963

MRPS30

0.962

MRPL28

0.962

MRPL41

0.961

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GADD45GIP1	MRPL10	ENSP00000323065	ENSP00000290208	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	Mitochondrial ribosomal protein L10; Belongs to the universal ribosomal protein uL10 family.	0.973
GADD45GIP1	MRPL28	ENSP00000323065	ENSP00000497004	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	Mitochondrial ribosomal protein L28.	0.989
GADD45GIP1	MRPL39	ENSP00000323065	ENSP00000305682	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	Mitochondrial ribosomal protein L39; Belongs to the mitochondrion-specific ribosomal protein mL39 family.	0.961
GADD45GIP1	MRPL4	ENSP00000323065	ENSP00000306902	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	Mitochondrial ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family.	0.989
GADD45GIP1	MRPL41	ENSP00000323065	ENSP00000360498	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.	0.986
GADD45GIP1	MRPL47	ENSP00000323065	ENSP00000417602	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	Mitochondrial ribosomal protein L47; Belongs to the universal ribosomal protein uL29 family.	0.980
GADD45GIP1	MRPL50	ENSP00000323065	ENSP00000363999	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	Mitochondrial ribosomal protein L50.	0.977
GADD45GIP1	MRPL52	ENSP00000323065	ENSP00000347277	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	Mitochondrial ribosomal protein L52.	0.981
GADD45GIP1	MRPL57	ENSP00000323065	ENSP00000310726	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	Mitochondrial ribosomal protein L57; Belongs to the mitochondrion-specific ribosomal protein mL63 family.	0.972
GADD45GIP1	MRPS30	ENSP00000323065	ENSP00000424328	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	Mitochondrial ribosomal protein S30.	0.983
MRPL10	GADD45GIP1	ENSP00000290208	ENSP00000323065	Mitochondrial ribosomal protein L10; Belongs to the universal ribosomal protein uL10 family.	Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis; Belongs to the mitochondrion-specific ribosomal protei [...]	0.973
MRPL10	MRPL28	ENSP00000290208	ENSP00000497004	Mitochondrial ribosomal protein L10; Belongs to the universal ribosomal protein uL10 family.	Mitochondrial ribosomal protein L28.	0.949
MRPL10	MRPL39	ENSP00000290208	ENSP00000305682	Mitochondrial ribosomal protein L10; Belongs to the universal ribosomal protein uL10 family.	Mitochondrial ribosomal protein L39; Belongs to the mitochondrion-specific ribosomal protein mL39 family.	0.976
MRPL10	MRPL4	ENSP00000290208	ENSP00000306902	Mitochondrial ribosomal protein L10; Belongs to the universal ribosomal protein uL10 family.	Mitochondrial ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family.	0.996
MRPL10	MRPL41	ENSP00000290208	ENSP00000360498	Mitochondrial ribosomal protein L10; Belongs to the universal ribosomal protein uL10 family.	39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.	0.993
MRPL10	MRPL47	ENSP00000290208	ENSP00000417602	Mitochondrial ribosomal protein L10; Belongs to the universal ribosomal protein uL10 family.	Mitochondrial ribosomal protein L47; Belongs to the universal ribosomal protein uL29 family.	0.991
MRPL10	MRPL50	ENSP00000290208	ENSP00000363999	Mitochondrial ribosomal protein L10; Belongs to the universal ribosomal protein uL10 family.	Mitochondrial ribosomal protein L50.	0.965
MRPL10	MRPL52	ENSP00000290208	ENSP00000347277	Mitochondrial ribosomal protein L10; Belongs to the universal ribosomal protein uL10 family.	Mitochondrial ribosomal protein L52.	0.928
MRPL10	MRPL57	ENSP00000290208	ENSP00000310726	Mitochondrial ribosomal protein L10; Belongs to the universal ribosomal protein uL10 family.	Mitochondrial ribosomal protein L57; Belongs to the mitochondrion-specific ribosomal protein mL63 family.	0.968
MRPL10	MRPS30	ENSP00000290208	ENSP00000424328	Mitochondrial ribosomal protein L10; Belongs to the universal ribosomal protein uL10 family.	Mitochondrial ribosomal protein S30.	0.969