node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GALNS | GNS | ENSP00000268695 | ENSP00000258145 | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family. | N-acetylglucosamine-6-sulfatase; Glucosamine-6-sulfatase; Belongs to the sulfatase family. | 0.612 |
GALNS | HGSNAT | ENSP00000268695 | ENSP00000368965 | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family. | Heparan-alpha-glucosaminide N-acetyltransferase; Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. | 0.659 |
GALNS | IDUA | ENSP00000268695 | ENSP00000247933 | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family. | alpha-L-iduronidase. | 0.783 |
GALNS | NAGLU | ENSP00000268695 | ENSP00000225927 | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family. | Alpha-N-acetylglucosaminidase 77 kDa form; Involved in the degradation of heparan sulfate. | 0.742 |
GALNS | SGSH | ENSP00000268695 | ENSP00000314606 | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family. | N-sulphoglucosamine sulphohydrolase; Catalyzes a step in lysosomal heparan sulfate degradation. Belongs to the sulfatase family. | 0.592 |
GNS | GALNS | ENSP00000258145 | ENSP00000268695 | N-acetylglucosamine-6-sulfatase; Glucosamine-6-sulfatase; Belongs to the sulfatase family. | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family. | 0.612 |
GNS | HGSNAT | ENSP00000258145 | ENSP00000368965 | N-acetylglucosamine-6-sulfatase; Glucosamine-6-sulfatase; Belongs to the sulfatase family. | Heparan-alpha-glucosaminide N-acetyltransferase; Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. | 0.797 |
GNS | IDUA | ENSP00000258145 | ENSP00000247933 | N-acetylglucosamine-6-sulfatase; Glucosamine-6-sulfatase; Belongs to the sulfatase family. | alpha-L-iduronidase. | 0.581 |
GNS | LAMP2 | ENSP00000258145 | ENSP00000408411 | N-acetylglucosamine-6-sulfatase; Glucosamine-6-sulfatase; Belongs to the sulfatase family. | Lysosome-associated membrane glycoprotein 2; Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live. Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation. Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy. Cells that lack LAMP2 express normal levels o [...] | 0.426 |
GNS | NAGLU | ENSP00000258145 | ENSP00000225927 | N-acetylglucosamine-6-sulfatase; Glucosamine-6-sulfatase; Belongs to the sulfatase family. | Alpha-N-acetylglucosaminidase 77 kDa form; Involved in the degradation of heparan sulfate. | 0.959 |
GNS | SGSH | ENSP00000258145 | ENSP00000314606 | N-acetylglucosamine-6-sulfatase; Glucosamine-6-sulfatase; Belongs to the sulfatase family. | N-sulphoglucosamine sulphohydrolase; Catalyzes a step in lysosomal heparan sulfate degradation. Belongs to the sulfatase family. | 0.618 |
HGSNAT | GALNS | ENSP00000368965 | ENSP00000268695 | Heparan-alpha-glucosaminide N-acetyltransferase; Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family. | 0.659 |
HGSNAT | GNS | ENSP00000368965 | ENSP00000258145 | Heparan-alpha-glucosaminide N-acetyltransferase; Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. | N-acetylglucosamine-6-sulfatase; Glucosamine-6-sulfatase; Belongs to the sulfatase family. | 0.797 |
HGSNAT | IDUA | ENSP00000368965 | ENSP00000247933 | Heparan-alpha-glucosaminide N-acetyltransferase; Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. | alpha-L-iduronidase. | 0.622 |
HGSNAT | NAGLU | ENSP00000368965 | ENSP00000225927 | Heparan-alpha-glucosaminide N-acetyltransferase; Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. | Alpha-N-acetylglucosaminidase 77 kDa form; Involved in the degradation of heparan sulfate. | 0.998 |
HGSNAT | SGSH | ENSP00000368965 | ENSP00000314606 | Heparan-alpha-glucosaminide N-acetyltransferase; Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. | N-sulphoglucosamine sulphohydrolase; Catalyzes a step in lysosomal heparan sulfate degradation. Belongs to the sulfatase family. | 0.981 |
HSD17B1 | NAGLU | ENSP00000225929 | ENSP00000225927 | Estradiol 17-beta-dehydrogenase 1; Favors the reduction of estrogens and androgens. Also has 20- alpha-HSD activity. Uses preferentially NADH; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Alpha-N-acetylglucosaminidase 77 kDa form; Involved in the degradation of heparan sulfate. | 0.764 |
IDUA | GALNS | ENSP00000247933 | ENSP00000268695 | alpha-L-iduronidase. | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family. | 0.783 |
IDUA | GNS | ENSP00000247933 | ENSP00000258145 | alpha-L-iduronidase. | N-acetylglucosamine-6-sulfatase; Glucosamine-6-sulfatase; Belongs to the sulfatase family. | 0.581 |
IDUA | HGSNAT | ENSP00000247933 | ENSP00000368965 | alpha-L-iduronidase. | Heparan-alpha-glucosaminide N-acetyltransferase; Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. | 0.622 |