node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC90B | NIPAL2 | ENSP00000434724 | ENSP00000407087 | Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B. | NIPA-like protein 2; NIPA like domain containing 2; Belongs to the NIPA family. | 0.565 |
CCDC90B | WDR74 | ENSP00000434724 | ENSP00000432119 | Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B. | WD repeat-containing protein 74; Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit. Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL. Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development (By similarity). | 0.494 |
CNNM1 | MAGT1 | ENSP00000349147 | ENSP00000354649 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Magnesium transporter protein 1; Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulf [...] | 0.448 |
CNNM1 | NIPAL2 | ENSP00000349147 | ENSP00000407087 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | NIPA-like protein 2; NIPA like domain containing 2; Belongs to the NIPA family. | 0.495 |
CNNM1 | PTP4A2 | ENSP00000349147 | ENSP00000493688 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. | 0.786 |
CNNM1 | SLC41A1 | ENSP00000349147 | ENSP00000356105 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Solute carrier family 41 member 1; Acts as a magnesium transporter that is responsive to magnesium balance. | 0.676 |
CNNM1 | TRPM6 | ENSP00000349147 | ENSP00000354006 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Transient receptor potential cation channel subfamily M member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region; In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM6 sub-subfamily. | 0.703 |
CNNM2 | MAGT1 | ENSP00000358894 | ENSP00000354649 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | Magnesium transporter protein 1; Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulf [...] | 0.595 |
CNNM2 | NIPAL2 | ENSP00000358894 | ENSP00000407087 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | NIPA-like protein 2; NIPA like domain containing 2; Belongs to the NIPA family. | 0.604 |
CNNM2 | PTP4A2 | ENSP00000358894 | ENSP00000493688 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | Protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. | 0.795 |
CNNM2 | SLC41A1 | ENSP00000358894 | ENSP00000356105 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | Solute carrier family 41 member 1; Acts as a magnesium transporter that is responsive to magnesium balance. | 0.788 |
CNNM2 | TRPM6 | ENSP00000358894 | ENSP00000354006 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | Transient receptor potential cation channel subfamily M member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region; In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM6 sub-subfamily. | 0.784 |
CNNM3 | CNNM4 | ENSP00000305449 | ENSP00000366275 | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | Metal transporter CNNM4; Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. | 0.419 |
CNNM3 | NIPAL2 | ENSP00000305449 | ENSP00000407087 | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | NIPA-like protein 2; NIPA like domain containing 2; Belongs to the NIPA family. | 0.595 |
CNNM3 | PTP4A2 | ENSP00000305449 | ENSP00000493688 | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | Protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. | 0.998 |
CNNM3 | SLC41A1 | ENSP00000305449 | ENSP00000356105 | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | Solute carrier family 41 member 1; Acts as a magnesium transporter that is responsive to magnesium balance. | 0.686 |
CNNM3 | TRPM6 | ENSP00000305449 | ENSP00000354006 | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | Transient receptor potential cation channel subfamily M member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region; In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM6 sub-subfamily. | 0.602 |
CNNM4 | CNNM3 | ENSP00000366275 | ENSP00000305449 | Metal transporter CNNM4; Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | 0.419 |
CNNM4 | MAGT1 | ENSP00000366275 | ENSP00000354649 | Metal transporter CNNM4; Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. | Magnesium transporter protein 1; Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulf [...] | 0.462 |
CNNM4 | NIPAL2 | ENSP00000366275 | ENSP00000407087 | Metal transporter CNNM4; Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. | NIPA-like protein 2; NIPA like domain containing 2; Belongs to the NIPA family. | 0.557 |