node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDH18A1 | LGSN | ENSP00000360268 | ENSP00000359691 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. | Lengsin; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity); Belongs to the glutamine synthetase family. | 0.429 |
ALDH18A1 | NOXRED1 | ENSP00000360268 | ENSP00000370215 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | 0.742 |
ALDH18A1 | OAT | ENSP00000360268 | ENSP00000357838 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. | Ornithine aminotransferase, mitochondrial; Ornithine aminotransferase. | 0.998 |
ALDH18A1 | TMED8 | ENSP00000360268 | ENSP00000216468 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. | Protein TMED8; Transmembrane p24 trafficking protein family member 8. | 0.710 |
C14orf178 | NOXRED1 | ENSP00000348145 | ENSP00000370215 | Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178. | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | 0.634 |
C14orf178 | SAMD15 | ENSP00000348145 | ENSP00000216471 | Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178. | Sterile alpha motif domain containing 15. | 0.659 |
C14orf178 | TMED8 | ENSP00000348145 | ENSP00000216468 | Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178. | Protein TMED8; Transmembrane p24 trafficking protein family member 8. | 0.577 |
C14orf178 | VIPAS39 | ENSP00000348145 | ENSP00000452181 | Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178. | Spermatogenesis-defective protein 39 homolog; Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B. May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indir [...] | 0.431 |
L3HYPDH | NOXRED1 | ENSP00000247194 | ENSP00000370215 | Trans-3-hydroxy-L-proline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it. | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | 0.549 |
L3HYPDH | TMED8 | ENSP00000247194 | ENSP00000216468 | Trans-3-hydroxy-L-proline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it. | Protein TMED8; Transmembrane p24 trafficking protein family member 8. | 0.550 |
LGSN | ALDH18A1 | ENSP00000359691 | ENSP00000360268 | Lengsin; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity); Belongs to the glutamine synthetase family. | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. | 0.429 |
LGSN | NOXRED1 | ENSP00000359691 | ENSP00000370215 | Lengsin; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity); Belongs to the glutamine synthetase family. | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | 0.539 |
LGSN | OAT | ENSP00000359691 | ENSP00000357838 | Lengsin; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity); Belongs to the glutamine synthetase family. | Ornithine aminotransferase, mitochondrial; Ornithine aminotransferase. | 0.436 |
MPZL1 | NOXRED1 | ENSP00000352513 | ENSP00000370215 | Myelin protein zero-like protein 1; Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | 0.591 |
NOXRED1 | ALDH18A1 | ENSP00000370215 | ENSP00000360268 | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. | 0.742 |
NOXRED1 | C14orf178 | ENSP00000370215 | ENSP00000348145 | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178. | 0.634 |
NOXRED1 | L3HYPDH | ENSP00000370215 | ENSP00000247194 | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | Trans-3-hydroxy-L-proline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it. | 0.549 |
NOXRED1 | LGSN | ENSP00000370215 | ENSP00000359691 | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | Lengsin; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity); Belongs to the glutamine synthetase family. | 0.539 |
NOXRED1 | MPZL1 | ENSP00000370215 | ENSP00000352513 | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | Myelin protein zero-like protein 1; Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. | 0.591 |
NOXRED1 | OAT | ENSP00000370215 | ENSP00000357838 | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | Ornithine aminotransferase, mitochondrial; Ornithine aminotransferase. | 0.481 |