STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NXPE4NXPE family member 4; Neurexophilin and PC-esterase domain family member 4; Belongs to the NXPE family. (544 aa)    
Predicted Functional Partners:
NXPE1
NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family.
  
  
0.792
MS4A12
Membrane-spanning 4-domains subfamily A member 12; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family.
   
  
 0.545
CEACAM7
CEA cell adhesion molecule 7; Belongs to the immunoglobulin superfamily. CEA family.
   
 
 0.523
SAMD13
Sterile alpha motif domain containing 13.
   
  
 0.519
REP15
Rab15 effector protein; Regulates transferrin receptor recycling from the endocytic recycling compartment.
      
 0.479
CLCA1
Calcium-activated chloride channel regulator 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
   
  
 0.456
VSIG2
V-set and immunoglobulin domain containing 2.
  
  
 0.435
ZNF726
Zinc finger protein 726; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
      
 0.402
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.