node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS2 | COL5A2 | ENSP00000251582 | ENSP00000364000 | A disintegrin and metalloproteinase with thrombospondin motifs 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity. | Collagen alpha-2(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity). | 0.797 |
ADAMTS2 | OLFML2B | ENSP00000251582 | ENSP00000356917 | A disintegrin and metalloproteinase with thrombospondin motifs 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity. | Olfactomedin-like protein 2B; Olfactomedin like 2B. | 0.457 |
C1orf226 | NOS1AP | ENSP00000413150 | ENSP00000355133 | Uncharacterized protein C1orf226; Chromosome 1 open reading frame 226. | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). | 0.943 |
C1orf226 | OLFML2B | ENSP00000413150 | ENSP00000356917 | Uncharacterized protein C1orf226; Chromosome 1 open reading frame 226. | Olfactomedin-like protein 2B; Olfactomedin like 2B. | 0.462 |
COL5A2 | ADAMTS2 | ENSP00000364000 | ENSP00000251582 | Collagen alpha-2(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity). | A disintegrin and metalloproteinase with thrombospondin motifs 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity. | 0.797 |
COL5A2 | CTHRC1 | ENSP00000364000 | ENSP00000330523 | Collagen alpha-2(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity). | Collagen triple helix repeat-containing protein 1; May act as a negative regulator of collagen matrix deposition. | 0.598 |
COL5A2 | MXRA5 | ENSP00000364000 | ENSP00000217939 | Collagen alpha-2(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity). | Matrix-remodeling-associated protein 5; In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli. | 0.584 |
COL5A2 | OLFML2B | ENSP00000364000 | ENSP00000356917 | Collagen alpha-2(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity). | Olfactomedin-like protein 2B; Olfactomedin like 2B. | 0.449 |
CTHRC1 | COL5A2 | ENSP00000330523 | ENSP00000364000 | Collagen triple helix repeat-containing protein 1; May act as a negative regulator of collagen matrix deposition. | Collagen alpha-2(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity). | 0.598 |
CTHRC1 | MXRA5 | ENSP00000330523 | ENSP00000217939 | Collagen triple helix repeat-containing protein 1; May act as a negative regulator of collagen matrix deposition. | Matrix-remodeling-associated protein 5; In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli. | 0.419 |
CTHRC1 | OLFML2B | ENSP00000330523 | ENSP00000356917 | Collagen triple helix repeat-containing protein 1; May act as a negative regulator of collagen matrix deposition. | Olfactomedin-like protein 2B; Olfactomedin like 2B. | 0.428 |
ISLR | OLFML2B | ENSP00000249842 | ENSP00000356917 | Immunoglobulin superfamily containing leucine rich repeat. | Olfactomedin-like protein 2B; Olfactomedin like 2B. | 0.432 |
MXRA5 | COL5A2 | ENSP00000217939 | ENSP00000364000 | Matrix-remodeling-associated protein 5; In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli. | Collagen alpha-2(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity). | 0.584 |
MXRA5 | CTHRC1 | ENSP00000217939 | ENSP00000330523 | Matrix-remodeling-associated protein 5; In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli. | Collagen triple helix repeat-containing protein 1; May act as a negative regulator of collagen matrix deposition. | 0.419 |
MXRA5 | OLFML2B | ENSP00000217939 | ENSP00000356917 | Matrix-remodeling-associated protein 5; In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli. | Olfactomedin-like protein 2B; Olfactomedin like 2B. | 0.484 |
NOS1AP | C1orf226 | ENSP00000355133 | ENSP00000413150 | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). | Uncharacterized protein C1orf226; Chromosome 1 open reading frame 226. | 0.943 |
NOS1AP | OLFML2B | ENSP00000355133 | ENSP00000356917 | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). | Olfactomedin-like protein 2B; Olfactomedin like 2B. | 0.488 |
NOS1AP | TOR3A | ENSP00000355133 | ENSP00000356599 | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). | Torsin-3A; Torsin family 3 member A. | 0.409 |
OLFML2B | ADAMTS2 | ENSP00000356917 | ENSP00000251582 | Olfactomedin-like protein 2B; Olfactomedin like 2B. | A disintegrin and metalloproteinase with thrombospondin motifs 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity. | 0.457 |
OLFML2B | C1orf226 | ENSP00000356917 | ENSP00000413150 | Olfactomedin-like protein 2B; Olfactomedin like 2B. | Uncharacterized protein C1orf226; Chromosome 1 open reading frame 226. | 0.462 |