node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP5PF | OTOR | ENSP00000389649 | ENSP00000246081 | ATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of t [...] | Otoraplin; Belongs to the MIA/OTOR family. | 0.506 |
CHRNA10 | OTOR | ENSP00000250699 | ENSP00000246081 | Neuronal acetylcholine receptor subunit alpha-10; Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion- conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reduci [...] | Otoraplin; Belongs to the MIA/OTOR family. | 0.446 |
CLDN17 | OTOR | ENSP00000286808 | ENSP00000246081 | Claudin-17; Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability; Belongs to the claudin family. | Otoraplin; Belongs to the MIA/OTOR family. | 0.418 |
CTAGE15 | OTOR | ENSP00000474204 | ENSP00000246081 | CTAGE family member 15. | Otoraplin; Belongs to the MIA/OTOR family. | 0.476 |
CTAGE6 | OTOR | ENSP00000474388 | ENSP00000246081 | CTAGE family member 6. | Otoraplin; Belongs to the MIA/OTOR family. | 0.447 |
CTAGE8 | OTOR | ENSP00000417289 | ENSP00000246081 | CTAGE family member 8. | Otoraplin; Belongs to the MIA/OTOR family. | 0.433 |
CTAGE9 | OTOR | ENSP00000395587 | ENSP00000246081 | CTAGE family member 9. | Otoraplin; Belongs to the MIA/OTOR family. | 0.509 |
OTOA | OTOR | ENSP00000496564 | ENSP00000246081 | Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family. | Otoraplin; Belongs to the MIA/OTOR family. | 0.431 |
OTOA | OTOS | ENSP00000496564 | ENSP00000375849 | Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family. | Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear. | 0.537 |
OTOR | ATP5PF | ENSP00000246081 | ENSP00000389649 | Otoraplin; Belongs to the MIA/OTOR family. | ATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of t [...] | 0.506 |
OTOR | CHRNA10 | ENSP00000246081 | ENSP00000250699 | Otoraplin; Belongs to the MIA/OTOR family. | Neuronal acetylcholine receptor subunit alpha-10; Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion- conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reduci [...] | 0.446 |
OTOR | CLDN17 | ENSP00000246081 | ENSP00000286808 | Otoraplin; Belongs to the MIA/OTOR family. | Claudin-17; Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability; Belongs to the claudin family. | 0.418 |
OTOR | CTAGE15 | ENSP00000246081 | ENSP00000474204 | Otoraplin; Belongs to the MIA/OTOR family. | CTAGE family member 15. | 0.476 |
OTOR | CTAGE6 | ENSP00000246081 | ENSP00000474388 | Otoraplin; Belongs to the MIA/OTOR family. | CTAGE family member 6. | 0.447 |
OTOR | CTAGE8 | ENSP00000246081 | ENSP00000417289 | Otoraplin; Belongs to the MIA/OTOR family. | CTAGE family member 8. | 0.433 |
OTOR | CTAGE9 | ENSP00000246081 | ENSP00000395587 | Otoraplin; Belongs to the MIA/OTOR family. | CTAGE family member 9. | 0.509 |
OTOR | OTOA | ENSP00000246081 | ENSP00000496564 | Otoraplin; Belongs to the MIA/OTOR family. | Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family. | 0.431 |
OTOR | OTOS | ENSP00000246081 | ENSP00000375849 | Otoraplin; Belongs to the MIA/OTOR family. | Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear. | 0.541 |
OTOR | SPAG4 | ENSP00000246081 | ENSP00000363391 | Otoraplin; Belongs to the MIA/OTOR family. | Sperm-associated antigen 4 protein; Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODF [...] | 0.439 |
OTOS | OTOA | ENSP00000375849 | ENSP00000496564 | Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear. | Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family. | 0.537 |