node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COL1A1 | COL1A2 | ENSP00000225964 | ENSP00000297268 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. | 0.999 |
COL1A1 | COL5A1 | ENSP00000225964 | ENSP00000360882 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Collagen alpha-1(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. | 0.994 |
COL1A1 | CRTAP | ENSP00000225964 | ENSP00000323696 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Cartilage-associated protein; Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues; Belongs to the leprecan family. | 0.971 |
COL1A1 | FKBP10 | ENSP00000225964 | ENSP00000317232 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Peptidyl-prolyl cis-trans isomerase FKBP10; PPIases accelerate the folding of proteins during protein synthesis. | 0.804 |
COL1A1 | P3H1 | ENSP00000225964 | ENSP00000236040 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Prolyl 3-hydroxylase 1; Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts. | 0.945 |
COL1A1 | P4HA2 | ENSP00000225964 | ENSP00000384999 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Prolyl 4-hydroxylase subunit alpha-2; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. | 0.863 |
COL1A1 | P4HB | ENSP00000225964 | ENSP00000327801 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Protein disulfide-isomerase; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chape [...] | 0.763 |
COL1A1 | PPIB | ENSP00000225964 | ENSP00000300026 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Peptidyl-prolyl cis-trans isomerase B; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. | 0.893 |
COL1A1 | SERPINH1 | ENSP00000225964 | ENSP00000434412 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Serpin H1; Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. | 0.921 |
COL1A1 | TMEM38B | ENSP00000225964 | ENSP00000363824 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | Trimeric intracellular cation channel type B; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores; Belongs to the TMEM38 family. | 0.542 |
COL1A2 | COL1A1 | ENSP00000297268 | ENSP00000225964 | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). | 0.999 |
COL1A2 | COL5A1 | ENSP00000297268 | ENSP00000360882 | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. | Collagen alpha-1(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. | 0.989 |
COL1A2 | CRTAP | ENSP00000297268 | ENSP00000323696 | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. | Cartilage-associated protein; Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues; Belongs to the leprecan family. | 0.964 |
COL1A2 | FKBP10 | ENSP00000297268 | ENSP00000317232 | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. | Peptidyl-prolyl cis-trans isomerase FKBP10; PPIases accelerate the folding of proteins during protein synthesis. | 0.871 |
COL1A2 | P3H1 | ENSP00000297268 | ENSP00000236040 | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. | Prolyl 3-hydroxylase 1; Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts. | 0.945 |
COL1A2 | P4HA2 | ENSP00000297268 | ENSP00000384999 | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. | Prolyl 4-hydroxylase subunit alpha-2; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. | 0.679 |
COL1A2 | P4HB | ENSP00000297268 | ENSP00000327801 | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. | Protein disulfide-isomerase; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chape [...] | 0.662 |
COL1A2 | PPIB | ENSP00000297268 | ENSP00000300026 | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. | Peptidyl-prolyl cis-trans isomerase B; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. | 0.876 |
COL1A2 | SERPINH1 | ENSP00000297268 | ENSP00000434412 | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. | Serpin H1; Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. | 0.879 |
COL1A2 | TMEM38B | ENSP00000297268 | ENSP00000363824 | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. | Trimeric intracellular cation channel type B; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores; Belongs to the TMEM38 family. | 0.582 |