PBDC1 protein (human) - STRING interaction network

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PBDC1

Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family. (233 aa)

Predicted Functional Partners:

TTLL12

0.832

EEF1A1

0.823

EEF1A2

0.633

SBNO1

0.618

ZDHHC24

0.570

PDCD5

0.544

LRRC42

0.506

MYSM1

0.492

TIMM17B

0.486

SHROOM4

0.464

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EEF1A1	EEF1A2	ENSP00000339063	ENSP00000217182	Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	Elongation factor 1-alpha 2; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	0.994
EEF1A1	PBDC1	ENSP00000339063	ENSP00000362456	Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family.	0.823
EEF1A1	PDCD5	ENSP00000339063	ENSP00000466214	Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	Programmed cell death protein 5; May function in the process of apoptosis.	0.410
EEF1A1	TTLL12	ENSP00000339063	ENSP00000216129	Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	Tubulin--tyrosine ligase-like protein 12; Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE.	0.808
EEF1A2	EEF1A1	ENSP00000217182	ENSP00000339063	Elongation factor 1-alpha 2; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	0.994
EEF1A2	PBDC1	ENSP00000217182	ENSP00000362456	Elongation factor 1-alpha 2; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family.	0.633
EEF1A2	TTLL12	ENSP00000217182	ENSP00000216129	Elongation factor 1-alpha 2; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	Tubulin--tyrosine ligase-like protein 12; Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE.	0.724
LRRC42	PBDC1	ENSP00000360421	ENSP00000362456	Leucine-rich repeat-containing protein 42; Leucine rich repeat containing 42; Belongs to the LRRC42 family.	Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family.	0.506
MYSM1	PBDC1	ENSP00000418734	ENSP00000362456	Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Required for correct regulation of hematopoiesis [...]	Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family.	0.492
PBDC1	EEF1A1	ENSP00000362456	ENSP00000339063	Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family.	Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	0.823
PBDC1	EEF1A2	ENSP00000362456	ENSP00000217182	Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family.	Elongation factor 1-alpha 2; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	0.633
PBDC1	LRRC42	ENSP00000362456	ENSP00000360421	Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family.	Leucine-rich repeat-containing protein 42; Leucine rich repeat containing 42; Belongs to the LRRC42 family.	0.506
PBDC1	MYSM1	ENSP00000362456	ENSP00000418734	Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family.	Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Required for correct regulation of hematopoiesis [...]	0.492
PBDC1	PDCD5	ENSP00000362456	ENSP00000466214	Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family.	Programmed cell death protein 5; May function in the process of apoptosis.	0.544
PBDC1	SBNO1	ENSP00000362456	ENSP00000473665	Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family.	Strawberry notch homolog 1.	0.618
PBDC1	SHROOM4	ENSP00000362456	ENSP00000365188	Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family.	Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity); Belongs to the shroom family.	0.464
PBDC1	TIMM17B	ENSP00000362456	ENSP00000379999	Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family.	Mitochondrial import inner membrane translocase subunit Tim17-B; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.486
PBDC1	TTLL12	ENSP00000362456	ENSP00000216129	Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family.	Tubulin--tyrosine ligase-like protein 12; Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE.	0.832
PBDC1	ZDHHC24	ENSP00000362456	ENSP00000309429	Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family.	Probable palmitoyltransferase ZDHHC24; Zinc finger DHHC-type containing 24; Belongs to the DHHC palmitoyltransferase family.	0.570
PDCD5	EEF1A1	ENSP00000466214	ENSP00000339063	Programmed cell death protein 5; May function in the process of apoptosis.	Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.	0.410