node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFAP1L1 | PCYOX1L | ENSP00000296721 | ENSP00000274569 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation. | Prenylcysteine oxidase-like; Probable oxidoreductase. | 0.456 |
ARRDC3 | PCYOX1L | ENSP00000265138 | ENSP00000274569 | Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes. Belongs to the arrestin family. | Prenylcysteine oxidase-like; Probable oxidoreductase. | 0.428 |
CD1B | PCYOX1L | ENSP00000357150 | ENSP00000274569 | T-cell surface glycoprotein CD1b; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. | Prenylcysteine oxidase-like; Probable oxidoreductase. | 0.401 |
EXD1 | PCYOX1L | ENSP00000415056 | ENSP00000274569 | piRNA biogenesis protein EXD1; RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loa [...] | Prenylcysteine oxidase-like; Probable oxidoreductase. | 0.409 |
EXD1 | ZDHHC24 | ENSP00000415056 | ENSP00000309429 | piRNA biogenesis protein EXD1; RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loa [...] | Probable palmitoyltransferase ZDHHC24; Zinc finger DHHC-type containing 24; Belongs to the DHHC palmitoyltransferase family. | 0.437 |
EXD1 | ZNF248 | ENSP00000415056 | ENSP00000379208 | piRNA biogenesis protein EXD1; RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loa [...] | Zinc finger protein 248; May be involved in transcriptional regulation. | 0.426 |
EXD1 | ZNF782 | ENSP00000415056 | ENSP00000419397 | piRNA biogenesis protein EXD1; RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loa [...] | Zinc finger protein 782; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.474 |
PCYOX1L | AFAP1L1 | ENSP00000274569 | ENSP00000296721 | Prenylcysteine oxidase-like; Probable oxidoreductase. | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation. | 0.456 |
PCYOX1L | ARRDC3 | ENSP00000274569 | ENSP00000265138 | Prenylcysteine oxidase-like; Probable oxidoreductase. | Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes. Belongs to the arrestin family. | 0.428 |
PCYOX1L | CD1B | ENSP00000274569 | ENSP00000357150 | Prenylcysteine oxidase-like; Probable oxidoreductase. | T-cell surface glycoprotein CD1b; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. | 0.401 |
PCYOX1L | EXD1 | ENSP00000274569 | ENSP00000415056 | Prenylcysteine oxidase-like; Probable oxidoreductase. | piRNA biogenesis protein EXD1; RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loa [...] | 0.409 |
PCYOX1L | PGAP2 | ENSP00000274569 | ENSP00000278243 | Prenylcysteine oxidase-like; Probable oxidoreductase. | Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity); Belongs to the PGAP2 family. | 0.417 |
PCYOX1L | USP39 | ENSP00000274569 | ENSP00000312981 | Prenylcysteine oxidase-like; Probable oxidoreductase. | U4/U6.U5 tri-snRNP-associated protein 2; Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity. | 0.424 |
PCYOX1L | VPS13B | ENSP00000274569 | ENSP00000351346 | Prenylcysteine oxidase-like; Probable oxidoreductase. | Vacuolar protein sorting-associated protein 13B; May be involved in protein sorting in post Golgi membrane traffic; Belongs to the VPS13 family. | 0.404 |
PCYOX1L | ZDHHC24 | ENSP00000274569 | ENSP00000309429 | Prenylcysteine oxidase-like; Probable oxidoreductase. | Probable palmitoyltransferase ZDHHC24; Zinc finger DHHC-type containing 24; Belongs to the DHHC palmitoyltransferase family. | 0.426 |
PCYOX1L | ZNF248 | ENSP00000274569 | ENSP00000379208 | Prenylcysteine oxidase-like; Probable oxidoreductase. | Zinc finger protein 248; May be involved in transcriptional regulation. | 0.428 |
PCYOX1L | ZNF782 | ENSP00000274569 | ENSP00000419397 | Prenylcysteine oxidase-like; Probable oxidoreductase. | Zinc finger protein 782; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.461 |
PGAP2 | PCYOX1L | ENSP00000278243 | ENSP00000274569 | Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity); Belongs to the PGAP2 family. | Prenylcysteine oxidase-like; Probable oxidoreductase. | 0.417 |
PGAP2 | VPS13B | ENSP00000278243 | ENSP00000351346 | Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity); Belongs to the PGAP2 family. | Vacuolar protein sorting-associated protein 13B; May be involved in protein sorting in post Golgi membrane traffic; Belongs to the VPS13 family. | 0.486 |
PGAP2 | ZDHHC24 | ENSP00000278243 | ENSP00000309429 | Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity); Belongs to the PGAP2 family. | Probable palmitoyltransferase ZDHHC24; Zinc finger DHHC-type containing 24; Belongs to the DHHC palmitoyltransferase family. | 0.408 |