node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC92 | PDGFRL | ENSP00000238156 | ENSP00000444211 | Coiled-coil domain containing 92. | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like. | 0.400 |
ERAL1 | PDGFRL | ENSP00000254928 | ENSP00000444211 | GTPase Era, mitochondrial; Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family. | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like. | 0.432 |
MOSPD1 | PDGFRL | ENSP00000359819 | ENSP00000444211 | Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to- mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation. | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like. | 0.412 |
OGN | PDGFRL | ENSP00000364711 | ENSP00000444211 | Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2. | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like. | 0.417 |
OGN | SFRP4 | ENSP00000364711 | ENSP00000410715 | Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2. | Secreted frizzled-related protein 4; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. | 0.508 |
PDGFC | PDGFRL | ENSP00000422464 | ENSP00000444211 | Platelet-derived growth factor C, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in [...] | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like. | 0.563 |
PDGFRL | CCDC92 | ENSP00000444211 | ENSP00000238156 | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like. | Coiled-coil domain containing 92. | 0.400 |
PDGFRL | ERAL1 | ENSP00000444211 | ENSP00000254928 | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like. | GTPase Era, mitochondrial; Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family. | 0.432 |
PDGFRL | MOSPD1 | ENSP00000444211 | ENSP00000359819 | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like. | Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to- mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation. | 0.412 |
PDGFRL | OGN | ENSP00000444211 | ENSP00000364711 | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like. | Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2. | 0.417 |
PDGFRL | PDGFC | ENSP00000444211 | ENSP00000422464 | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like. | Platelet-derived growth factor C, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in [...] | 0.563 |
PDGFRL | SCOC | ENSP00000444211 | ENSP00000477352 | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like. | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family. | 0.411 |
PDGFRL | SFRP4 | ENSP00000444211 | ENSP00000410715 | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like. | Secreted frizzled-related protein 4; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. | 0.405 |
PDGFRL | TUSC3 | ENSP00000444211 | ENSP00000424544 | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like. | Tumor suppressor candidate 3; Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfide [...] | 0.962 |
SCOC | PDGFRL | ENSP00000477352 | ENSP00000444211 | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family. | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like. | 0.411 |
SFRP4 | OGN | ENSP00000410715 | ENSP00000364711 | Secreted frizzled-related protein 4; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. | Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2. | 0.508 |
SFRP4 | PDGFRL | ENSP00000410715 | ENSP00000444211 | Secreted frizzled-related protein 4; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like. | 0.405 |
TUSC3 | PDGFRL | ENSP00000424544 | ENSP00000444211 | Tumor suppressor candidate 3; Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfide [...] | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like. | 0.962 |