node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARID3B | PHTF2 | ENSP00000477878 | ENSP00000403042 | AT-rich interactive domain-containing protein 3B; Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A. | Putative homeodomain transcription factor 2; May play a role in transcription regulation. | 0.430 |
C9orf135 | PHTF2 | ENSP00000366402 | ENSP00000403042 | Protein C9orf135; Chromosome 9 open reading frame 135. | Putative homeodomain transcription factor 2; May play a role in transcription regulation. | 0.405 |
FUNDC2 | PHTF2 | ENSP00000358510 | ENSP00000403042 | FUN14 domain containing 2; Belongs to the FUN14 family. | Putative homeodomain transcription factor 2; May play a role in transcription regulation. | 0.413 |
LYPD3 | PHTF2 | ENSP00000244333 | ENSP00000403042 | Ly6/PLAUR domain-containing protein 3; Supports cell migration. May be involved in urothelial cell- matrix interactions. May be involved in tumor progression. | Putative homeodomain transcription factor 2; May play a role in transcription regulation. | 0.423 |
MSL3 | PHTF1 | ENSP00000312244 | ENSP00000358617 | Male-specific lethal 3 homolog; Has a role in chromatin remodeling and transcriptional regulation. Has a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. | Putative homeodomain transcription factor 1; May play a role in transcription regulation. | 0.500 |
MSL3 | PHTF2 | ENSP00000312244 | ENSP00000403042 | Male-specific lethal 3 homolog; Has a role in chromatin remodeling and transcriptional regulation. Has a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. | Putative homeodomain transcription factor 2; May play a role in transcription regulation. | 0.480 |
PHTF1 | MSL3 | ENSP00000358617 | ENSP00000312244 | Putative homeodomain transcription factor 1; May play a role in transcription regulation. | Male-specific lethal 3 homolog; Has a role in chromatin remodeling and transcriptional regulation. Has a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. | 0.500 |
PHTF1 | PHTF2 | ENSP00000358617 | ENSP00000403042 | Putative homeodomain transcription factor 1; May play a role in transcription regulation. | Putative homeodomain transcription factor 2; May play a role in transcription regulation. | 0.628 |
PHTF2 | ARID3B | ENSP00000403042 | ENSP00000477878 | Putative homeodomain transcription factor 2; May play a role in transcription regulation. | AT-rich interactive domain-containing protein 3B; Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A. | 0.430 |
PHTF2 | C9orf135 | ENSP00000403042 | ENSP00000366402 | Putative homeodomain transcription factor 2; May play a role in transcription regulation. | Protein C9orf135; Chromosome 9 open reading frame 135. | 0.405 |
PHTF2 | FUNDC2 | ENSP00000403042 | ENSP00000358510 | Putative homeodomain transcription factor 2; May play a role in transcription regulation. | FUN14 domain containing 2; Belongs to the FUN14 family. | 0.413 |
PHTF2 | LYPD3 | ENSP00000403042 | ENSP00000244333 | Putative homeodomain transcription factor 2; May play a role in transcription regulation. | Ly6/PLAUR domain-containing protein 3; Supports cell migration. May be involved in urothelial cell- matrix interactions. May be involved in tumor progression. | 0.423 |
PHTF2 | MSL3 | ENSP00000403042 | ENSP00000312244 | Putative homeodomain transcription factor 2; May play a role in transcription regulation. | Male-specific lethal 3 homolog; Has a role in chromatin remodeling and transcriptional regulation. Has a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. | 0.480 |
PHTF2 | PHTF1 | ENSP00000403042 | ENSP00000358617 | Putative homeodomain transcription factor 2; May play a role in transcription regulation. | Putative homeodomain transcription factor 1; May play a role in transcription regulation. | 0.628 |
PHTF2 | POLR3D | ENSP00000403042 | ENSP00000380904 | Putative homeodomain transcription factor 2; May play a role in transcription regulation. | DNA-directed RNA polymerase III subunit RPC4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Ep [...] | 0.453 |
PHTF2 | SHPRH | ENSP00000403042 | ENSP00000275233 | Putative homeodomain transcription factor 2; May play a role in transcription regulation. | E3 ubiquitin-protein ligase SHPRH; E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly- ubiquitin chains linked through 'Lys-63'; Belongs to the SNF2/RAD54 helicase family. | 0.457 |
PHTF2 | SLF1 | ENSP00000403042 | ENSP00000265140 | Putative homeodomain transcription factor 2; May play a role in transcription regulation. | SMC5-SMC6 complex localization factor protein 1; Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions. | 0.497 |
PHTF2 | TMEM60 | ENSP00000403042 | ENSP00000257663 | Putative homeodomain transcription factor 2; May play a role in transcription regulation. | Transmembrane protein 60. | 0.440 |
POLR3D | PHTF2 | ENSP00000380904 | ENSP00000403042 | DNA-directed RNA polymerase III subunit RPC4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Ep [...] | Putative homeodomain transcription factor 2; May play a role in transcription regulation. | 0.453 |
SHPRH | PHTF2 | ENSP00000275233 | ENSP00000403042 | E3 ubiquitin-protein ligase SHPRH; E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly- ubiquitin chains linked through 'Lys-63'; Belongs to the SNF2/RAD54 helicase family. | Putative homeodomain transcription factor 2; May play a role in transcription regulation. | 0.457 |