node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKAP17A | ASMT | ENSP00000324827 | ENSP00000370639 | A-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. | Acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. | 0.788 |
AKAP17A | ASMTL | ENSP00000324827 | ENSP00000370718 | A-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. | Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo- UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methy [...] | 0.910 |
AKAP17A | DHRSX | ENSP00000324827 | ENSP00000334113 | A-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. | Dehydrogenase/reductase SDR family member on chromosome X; Involved in the positive regulation of starvation-induced autophagy ; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.694 |
AKAP17A | GTPBP6 | ENSP00000324827 | ENSP00000316598 | A-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. | GTP binding protein 6. | 0.720 |
AKAP17A | PLCXD1 | ENSP00000324827 | ENSP00000371073 | A-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. | PI-PLC X domain-containing protein 1; Phosphatidylinositol specific phospholipase C X domain containing 1. | 0.637 |
AKAP17A | PPP2R3B | ENSP00000324827 | ENSP00000375080 | A-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.441 |
AKAP17A | PUDP | ENSP00000324827 | ENSP00000396452 | A-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. | Pseudouridine-5'-phosphatase; Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | 0.411 |
AKAP17A | ZBED1 | ENSP00000324827 | ENSP00000370621 | A-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. | Zinc finger BED domain-containing protein 1; Binds to 5'-TGTCG[CT]GA[CT]A-3' DNA elements found in the promoter regions of a number of genes related to cell proliferation. Binds to the histone H1 promoter and stimulates transcription. Was first identified as gene weakly similar to Ac transposable elements, but does not code for any transposase activity. | 0.621 |
ASMT | AKAP17A | ENSP00000370639 | ENSP00000324827 | Acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. | A-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. | 0.788 |
ASMT | DHRSX | ENSP00000370639 | ENSP00000334113 | Acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. | Dehydrogenase/reductase SDR family member on chromosome X; Involved in the positive regulation of starvation-induced autophagy ; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.529 |
ASMT | GTPBP6 | ENSP00000370639 | ENSP00000316598 | Acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. | GTP binding protein 6. | 0.542 |
ASMT | PLCXD1 | ENSP00000370639 | ENSP00000371073 | Acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. | PI-PLC X domain-containing protein 1; Phosphatidylinositol specific phospholipase C X domain containing 1. | 0.624 |
ASMT | SHOX | ENSP00000370639 | ENSP00000370990 | Acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. | Short stature homeobox protein; Controls fundamental aspects of growth and development; Belongs to the paired homeobox family. Bicoid subfamily. | 0.646 |
ASMT | ZBED1 | ENSP00000370639 | ENSP00000370621 | Acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. | Zinc finger BED domain-containing protein 1; Binds to 5'-TGTCG[CT]GA[CT]A-3' DNA elements found in the promoter regions of a number of genes related to cell proliferation. Binds to the histone H1 promoter and stimulates transcription. Was first identified as gene weakly similar to Ac transposable elements, but does not code for any transposase activity. | 0.483 |
ASMTL | AKAP17A | ENSP00000370718 | ENSP00000324827 | Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo- UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methy [...] | A-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. | 0.910 |
ASMTL | DHRSX | ENSP00000370718 | ENSP00000334113 | Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo- UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methy [...] | Dehydrogenase/reductase SDR family member on chromosome X; Involved in the positive regulation of starvation-induced autophagy ; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.773 |
ASMTL | GTPBP6 | ENSP00000370718 | ENSP00000316598 | Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo- UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methy [...] | GTP binding protein 6. | 0.776 |
ASMTL | PLCXD1 | ENSP00000370718 | ENSP00000371073 | Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo- UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methy [...] | PI-PLC X domain-containing protein 1; Phosphatidylinositol specific phospholipase C X domain containing 1. | 0.743 |
ASMTL | PPP2R3B | ENSP00000370718 | ENSP00000375080 | Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo- UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methy [...] | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.634 |
ASMTL | PUDP | ENSP00000370718 | ENSP00000396452 | Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo- UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methy [...] | Pseudouridine-5'-phosphatase; Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. | 0.587 |