node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGAP25 | PLD5 | ENSP00000386911 | ENSP00000440896 | Rho GTPase-activating protein 25; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family. | 0.416 |
FAR2 | PLD5 | ENSP00000443291 | ENSP00000440896 | Fatty acyl-CoA reductase 2; Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity). | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family. | 0.423 |
NPSR1 | PLD5 | ENSP00000370950 | ENSP00000440896 | Neuropeptide S receptor; G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE- mediated diseases. | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family. | 0.407 |
PLD2 | PLD5 | ENSP00000263088 | ENSP00000440896 | Phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis. | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family. | 0.640 |
PLD2 | PLD6 | ENSP00000263088 | ENSP00000317177 | Phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis. | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Al [...] | 0.705 |
PLD5 | ARHGAP25 | ENSP00000440896 | ENSP00000386911 | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family. | Rho GTPase-activating protein 25; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. | 0.416 |
PLD5 | FAR2 | ENSP00000440896 | ENSP00000443291 | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family. | Fatty acyl-CoA reductase 2; Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity). | 0.423 |
PLD5 | NPSR1 | ENSP00000440896 | ENSP00000370950 | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family. | Neuropeptide S receptor; G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE- mediated diseases. | 0.407 |
PLD5 | PLD2 | ENSP00000440896 | ENSP00000263088 | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family. | Phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis. | 0.640 |
PLD5 | PLD6 | ENSP00000440896 | ENSP00000317177 | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family. | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Al [...] | 0.711 |
PLD5 | PNPLA8 | ENSP00000440896 | ENSP00000257694 | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family. | Calcium-independent phospholipase A2-gamma; Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids. | 0.433 |
PLD5 | SVOPL | ENSP00000440896 | ENSP00000405482 | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family. | Putative transporter SVOPL; SVOP like; Belongs to the major facilitator superfamily. | 0.405 |
PLD5 | WDR64 | ENSP00000440896 | ENSP00000355510 | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family. | WD repeat domain 64. | 0.508 |
PLD6 | PLD2 | ENSP00000317177 | ENSP00000263088 | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Al [...] | Phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis. | 0.705 |
PLD6 | PLD5 | ENSP00000317177 | ENSP00000440896 | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Al [...] | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family. | 0.711 |
PNPLA8 | PLD5 | ENSP00000257694 | ENSP00000440896 | Calcium-independent phospholipase A2-gamma; Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids. | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family. | 0.433 |
SVOPL | PLD5 | ENSP00000405482 | ENSP00000440896 | Putative transporter SVOPL; SVOP like; Belongs to the major facilitator superfamily. | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family. | 0.405 |
WDR64 | PLD5 | ENSP00000355510 | ENSP00000440896 | WD repeat domain 64. | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family. | 0.508 |