node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAM32 | HTRA4 | ENSP00000369238 | ENSP00000305919 | Disintegrin and metalloproteinase domain-containing protein 32; May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein. | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | 0.417 |
ADAM32 | PLEKHA2 | ENSP00000369238 | ENSP00000482228 | Disintegrin and metalloproteinase domain-containing protein 32; May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein. | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | 0.515 |
HTRA4 | ADAM32 | ENSP00000305919 | ENSP00000369238 | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | Disintegrin and metalloproteinase domain-containing protein 32; May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein. | 0.417 |
HTRA4 | PLEKHA2 | ENSP00000305919 | ENSP00000482228 | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | 0.544 |
HTRA4 | TM2D2 | ENSP00000305919 | ENSP00000416050 | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | TM2 domain containing 2. | 0.490 |
MPDZ | PLEKHA1 | ENSP00000320006 | ENSP00000357986 | Multiple PDZ domain protein; Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. | Pleckstrin homology domain-containing family A member 1; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. | 0.593 |
MPDZ | PLEKHA2 | ENSP00000320006 | ENSP00000482228 | Multiple PDZ domain protein; Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | 0.622 |
PLEK2 | PLEKHA2 | ENSP00000216446 | ENSP00000482228 | Pleckstrin-2; May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation. | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | 0.717 |
PLEKHA1 | MPDZ | ENSP00000357986 | ENSP00000320006 | Pleckstrin homology domain-containing family A member 1; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. | Multiple PDZ domain protein; Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. | 0.593 |
PLEKHA1 | PLEKHA2 | ENSP00000357986 | ENSP00000482228 | Pleckstrin homology domain-containing family A member 1; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | 0.738 |
PLEKHA1 | PTPN13 | ENSP00000357986 | ENSP00000394794 | Pleckstrin homology domain-containing family A member 1; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. | Tyrosine-protein phosphatase non-receptor type 13; Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2. Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 0.971 |
PLEKHA2 | ADAM32 | ENSP00000482228 | ENSP00000369238 | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | Disintegrin and metalloproteinase domain-containing protein 32; May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein. | 0.515 |
PLEKHA2 | HTRA4 | ENSP00000482228 | ENSP00000305919 | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family. | 0.544 |
PLEKHA2 | MPDZ | ENSP00000482228 | ENSP00000320006 | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | Multiple PDZ domain protein; Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. | 0.622 |
PLEKHA2 | PLEK2 | ENSP00000482228 | ENSP00000216446 | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | Pleckstrin-2; May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation. | 0.717 |
PLEKHA2 | PLEKHA1 | ENSP00000482228 | ENSP00000357986 | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | Pleckstrin homology domain-containing family A member 1; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. | 0.738 |
PLEKHA2 | PTPN13 | ENSP00000482228 | ENSP00000394794 | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | Tyrosine-protein phosphatase non-receptor type 13; Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2. Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. | 0.943 |
PLEKHA2 | SNTA1 | ENSP00000482228 | ENSP00000217381 | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | Alpha-1-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity). | 0.622 |
PLEKHA2 | SNTB2 | ENSP00000482228 | ENSP00000338191 | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | Beta-2-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. | 0.615 |
PLEKHA2 | TM2D2 | ENSP00000482228 | ENSP00000416050 | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | TM2 domain containing 2. | 0.620 |