node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CARS2 | PNMA8A | ENSP00000257347 | ENSP00000318131 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | Paraneoplastic antigen-like protein 8A; PNMA family member 8A. | 0.422 |
FANCM | MOAP1 | ENSP00000267430 | ENSP00000451594 | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | Modulator of apoptosis 1; Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation; Belongs to the PNMA family. | 0.532 |
FANCM | PNMA1 | ENSP00000267430 | ENSP00000318914 | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | Paraneoplastic antigen Ma1; PNMA family member 1; Belongs to the PNMA family. | 0.532 |
FANCM | PNMA8A | ENSP00000267430 | ENSP00000318131 | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | Paraneoplastic antigen-like protein 8A; PNMA family member 8A. | 0.532 |
FANCM | RTL6 | ENSP00000267430 | ENSP00000340434 | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | Retrotransposon Gag like 6. | 0.532 |
FANCM | ZCCHC12 | ENSP00000267430 | ENSP00000308921 | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | Zinc finger CCHC domain-containing protein 12; Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic- neuron-specific gene expression (By similarity). | 0.532 |
FANCM | ZCCHC18 | ENSP00000267430 | ENSP00000482195 | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | Zinc finger CCHC-type containing 18; Belongs to the ZCCHC12 family. | 0.532 |
LONRF2 | PNMA8A | ENSP00000377086 | ENSP00000318131 | LON peptidase N-terminal domain and ring finger 2. | Paraneoplastic antigen-like protein 8A; PNMA family member 8A. | 0.418 |
MOAP1 | FANCM | ENSP00000451594 | ENSP00000267430 | Modulator of apoptosis 1; Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation; Belongs to the PNMA family. | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | 0.532 |
MOAP1 | PNMA1 | ENSP00000451594 | ENSP00000318914 | Modulator of apoptosis 1; Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation; Belongs to the PNMA family. | Paraneoplastic antigen Ma1; PNMA family member 1; Belongs to the PNMA family. | 0.797 |
MOAP1 | PNMA8A | ENSP00000451594 | ENSP00000318131 | Modulator of apoptosis 1; Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation; Belongs to the PNMA family. | Paraneoplastic antigen-like protein 8A; PNMA family member 8A. | 0.662 |
NOBOX | PNMA8A | ENSP00000419457 | ENSP00000318131 | Homeobox protein NOBOX; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'. | Paraneoplastic antigen-like protein 8A; PNMA family member 8A. | 0.446 |
PGBD5 | PNMA8A | ENSP00000375733 | ENSP00000318131 | PiggyBac transposable element-derived protein 5; Transposase that mediates sequence-specific genomic rearrangements. Can induce genomic rearrangements that inactivate the HPRT1 gene. | Paraneoplastic antigen-like protein 8A; PNMA family member 8A. | 0.479 |
PNMA1 | FANCM | ENSP00000318914 | ENSP00000267430 | Paraneoplastic antigen Ma1; PNMA family member 1; Belongs to the PNMA family. | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | 0.532 |
PNMA1 | MOAP1 | ENSP00000318914 | ENSP00000451594 | Paraneoplastic antigen Ma1; PNMA family member 1; Belongs to the PNMA family. | Modulator of apoptosis 1; Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation; Belongs to the PNMA family. | 0.797 |
PNMA1 | PNMA8A | ENSP00000318914 | ENSP00000318131 | Paraneoplastic antigen Ma1; PNMA family member 1; Belongs to the PNMA family. | Paraneoplastic antigen-like protein 8A; PNMA family member 8A. | 0.798 |
PNMA1 | RTL6 | ENSP00000318914 | ENSP00000340434 | Paraneoplastic antigen Ma1; PNMA family member 1; Belongs to the PNMA family. | Retrotransposon Gag like 6. | 0.462 |
PNMA1 | ZCCHC12 | ENSP00000318914 | ENSP00000308921 | Paraneoplastic antigen Ma1; PNMA family member 1; Belongs to the PNMA family. | Zinc finger CCHC domain-containing protein 12; Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic- neuron-specific gene expression (By similarity). | 0.816 |
PNMA8A | CARS2 | ENSP00000318131 | ENSP00000257347 | Paraneoplastic antigen-like protein 8A; PNMA family member 8A. | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.422 |
PNMA8A | FANCM | ENSP00000318131 | ENSP00000267430 | Paraneoplastic antigen-like protein 8A; PNMA family member 8A. | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | 0.532 |