node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NT5DC2 | PPM1M | ENSP00000406933 | ENSP00000387046 | 5'-nucleotidase domain containing 2. | Protein phosphatase, Mg2+/Mn2+ dependent 1M. | 0.463 |
PHLPP1 | PPM1M | ENSP00000262719 | ENSP00000387046 | PH domain leucine-rich repeat-containing protein phosphatase 1; Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA. Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors [...] | Protein phosphatase, Mg2+/Mn2+ dependent 1M. | 0.429 |
PPM1D | PPM1M | ENSP00000306682 | ENSP00000387046 | Protein phosphatase 1D; Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity). | Protein phosphatase, Mg2+/Mn2+ dependent 1M. | 0.526 |
PPM1F | PPM1M | ENSP00000263212 | ENSP00000387046 | Protein phosphatase 1F; Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis. | Protein phosphatase, Mg2+/Mn2+ dependent 1M. | 0.615 |
PPM1F | PPTC7 | ENSP00000263212 | ENSP00000346255 | Protein phosphatase 1F; Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis. | Protein phosphatase PTC7 homolog; Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q. Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation. | 0.516 |
PPM1G | PPM1M | ENSP00000342778 | ENSP00000387046 | Protein phosphatase, Mg2+/Mn2+ dependent 1G. | Protein phosphatase, Mg2+/Mn2+ dependent 1M. | 0.598 |
PPM1G | PPTC7 | ENSP00000342778 | ENSP00000346255 | Protein phosphatase, Mg2+/Mn2+ dependent 1G. | Protein phosphatase PTC7 homolog; Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q. Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation. | 0.421 |
PPM1K | PPM1M | ENSP00000477341 | ENSP00000387046 | Protein phosphatase 1K, mitochondrial; Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development. | Protein phosphatase, Mg2+/Mn2+ dependent 1M. | 0.575 |
PPM1K | PPTC7 | ENSP00000477341 | ENSP00000346255 | Protein phosphatase 1K, mitochondrial; Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development. | Protein phosphatase PTC7 homolog; Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q. Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation. | 0.642 |
PPM1M | NT5DC2 | ENSP00000387046 | ENSP00000406933 | Protein phosphatase, Mg2+/Mn2+ dependent 1M. | 5'-nucleotidase domain containing 2. | 0.463 |
PPM1M | PHLPP1 | ENSP00000387046 | ENSP00000262719 | Protein phosphatase, Mg2+/Mn2+ dependent 1M. | PH domain leucine-rich repeat-containing protein phosphatase 1; Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA. Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors [...] | 0.429 |
PPM1M | PPM1D | ENSP00000387046 | ENSP00000306682 | Protein phosphatase, Mg2+/Mn2+ dependent 1M. | Protein phosphatase 1D; Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity). | 0.526 |
PPM1M | PPM1F | ENSP00000387046 | ENSP00000263212 | Protein phosphatase, Mg2+/Mn2+ dependent 1M. | Protein phosphatase 1F; Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis. | 0.615 |
PPM1M | PPM1G | ENSP00000387046 | ENSP00000342778 | Protein phosphatase, Mg2+/Mn2+ dependent 1M. | Protein phosphatase, Mg2+/Mn2+ dependent 1G. | 0.598 |
PPM1M | PPM1K | ENSP00000387046 | ENSP00000477341 | Protein phosphatase, Mg2+/Mn2+ dependent 1M. | Protein phosphatase 1K, mitochondrial; Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development. | 0.575 |
PPM1M | PPTC7 | ENSP00000387046 | ENSP00000346255 | Protein phosphatase, Mg2+/Mn2+ dependent 1M. | Protein phosphatase PTC7 homolog; Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q. Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation. | 0.565 |
PPM1M | PTPRU | ENSP00000387046 | ENSP00000334941 | Protein phosphatase, Mg2+/Mn2+ dependent 1M. | Receptor-type tyrosine-protein phosphatase U; Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis; Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. | 0.464 |
PPM1M | RILP | ENSP00000387046 | ENSP00000301336 | Protein phosphatase, Mg2+/Mn2+ dependent 1M. | Rab-interacting lysosomal protein; Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes. | 0.468 |
PPM1M | RILPL1 | ENSP00000387046 | ENSP00000366070 | Protein phosphatase, Mg2+/Mn2+ dependent 1M. | RILP-like protein 1; Plays a role in the regulation of cell shape and polarity (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (By similarity). Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution. Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis. ECO:0000250|UniPro [...] | 0.434 |
PPTC7 | PPM1F | ENSP00000346255 | ENSP00000263212 | Protein phosphatase PTC7 homolog; Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q. Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation. | Protein phosphatase 1F; Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis. | 0.516 |