node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP9B | SLC66A2 | ENSP00000398076 | ENSP00000380880 | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B. | Solute carrier family 66 member 2. | 0.658 |
ATP9B | ZNF407 | ENSP00000398076 | ENSP00000299687 | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B. | Zinc finger protein 407; May be involved in transcriptional regulation. | 0.446 |
CTDP1 | SLC66A2 | ENSP00000484525 | ENSP00000380880 | RNA polymerase II subunit A C-terminal domain phosphatase; Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M- phase-promoting factor (MPF)/CDK1 inactivation. | Solute carrier family 66 member 2. | 0.498 |
CTDP1 | TXNL4A | ENSP00000484525 | ENSP00000269601 | RNA polymerase II subunit A C-terminal domain phosphatase; Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M- phase-promoting factor (MPF)/CDK1 inactivation. | Thioredoxin-like protein 4A; Plays role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex); Belongs to the DIM1 family. | 0.431 |
FAM89B | PRPF38B | ENSP00000431459 | ENSP00000359042 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family. | Pre-mRNA-splicing factor 38B; May be required for pre-mRNA splicing. | 0.519 |
FAM89B | SCOC | ENSP00000431459 | ENSP00000477352 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family. | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family. | 0.506 |
FAM89B | SLC66A2 | ENSP00000431459 | ENSP00000380880 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family. | Solute carrier family 66 member 2. | 0.595 |
PRPF38B | FAM89B | ENSP00000359042 | ENSP00000431459 | Pre-mRNA-splicing factor 38B; May be required for pre-mRNA splicing. | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family. | 0.519 |
PRPF38B | SCOC | ENSP00000359042 | ENSP00000477352 | Pre-mRNA-splicing factor 38B; May be required for pre-mRNA splicing. | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family. | 0.456 |
PRPF38B | SLC66A2 | ENSP00000359042 | ENSP00000380880 | Pre-mRNA-splicing factor 38B; May be required for pre-mRNA splicing. | Solute carrier family 66 member 2. | 0.506 |
RBFA | SLC66A2 | ENSP00000305696 | ENSP00000380880 | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A. | Solute carrier family 66 member 2. | 0.599 |
RBFA | TXNL4A | ENSP00000305696 | ENSP00000269601 | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A. | Thioredoxin-like protein 4A; Plays role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex); Belongs to the DIM1 family. | 0.550 |
RBFA | ZNF516 | ENSP00000305696 | ENSP00000394757 | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A. | Zinc finger protein 516; Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress. | 0.426 |
SCOC | FAM89B | ENSP00000477352 | ENSP00000431459 | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family. | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family. | 0.506 |
SCOC | PRPF38B | ENSP00000477352 | ENSP00000359042 | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family. | Pre-mRNA-splicing factor 38B; May be required for pre-mRNA splicing. | 0.456 |
SCOC | SLC66A2 | ENSP00000477352 | ENSP00000380880 | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family. | Solute carrier family 66 member 2. | 0.496 |
SLC25A46 | SLC66A2 | ENSP00000348211 | ENSP00000380880 | Solute carrier family 25 member 46; May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Solute carrier family 66 member 2. | 0.529 |
SLC66A2 | ATP9B | ENSP00000380880 | ENSP00000398076 | Solute carrier family 66 member 2. | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B. | 0.658 |
SLC66A2 | CTDP1 | ENSP00000380880 | ENSP00000484525 | Solute carrier family 66 member 2. | RNA polymerase II subunit A C-terminal domain phosphatase; Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M- phase-promoting factor (MPF)/CDK1 inactivation. | 0.498 |
SLC66A2 | FAM89B | ENSP00000380880 | ENSP00000431459 | Solute carrier family 66 member 2. | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family. | 0.595 |