PRAMEF4 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PRAMEF4

PRAME family member 4; Belongs to the PRAME family (478 aa)

Predicted Functional Partners:

PRAMEF5

0.694

MBD3L2

0.559

PRAMEF11

0.541

PRAMEF8

0.521

ZSCAN4

0.469

PRAMEF9

0.458

CDH12

0.455

ANKRD36C

0.454

LRRC8E

0.454

DUX4L7

0.445

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD36C	PRAMEF4	ENSP00000403302	ENSP00000235349	Ankyrin repeat domain-containing protein 36C; Ankyrin repeat domain containing	PRAME family member 4; Belongs to the PRAME family	0.454
CDH12	PRAMEF11	ENSP00000371689	ENSP00000480027	Cadherin-12; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types	Prame family member 11; Belongs to the PRAME family	0.455
CDH12	PRAMEF4	ENSP00000371689	ENSP00000235349	Cadherin-12; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types	PRAME family member 4; Belongs to the PRAME family	0.455
CDH12	PRAMEF5	ENSP00000371689	ENSP00000480122	Cadherin-12; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types	PRAME family member 5; Belongs to the PRAME family	0.459
CDH12	PRAMEF8	ENSP00000371689	ENSP00000349931	Cadherin-12; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types	PRAME family member 8; Belongs to the PRAME family	0.414
CDH12	PRAMEF9	ENSP00000371689	ENSP00000365322	Cadherin-12; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types	Prame family member 9/15; PRAME family member 9; Belongs to the PRAME family	0.422
DUX4L7	MBD3L2	ENSP00000451411	ENSP00000370800	Double homeodomain protein dux4-s; Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	methyl-CpG binding domain protein 3 like 2; Belongs to the MBD3L family	0.612
DUX4L7	PRAMEF11	ENSP00000451411	ENSP00000480027	Double homeodomain protein dux4-s; Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	Prame family member 11; Belongs to the PRAME family	0.441
DUX4L7	PRAMEF4	ENSP00000451411	ENSP00000235349	Double homeodomain protein dux4-s; Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	PRAME family member 4; Belongs to the PRAME family	0.445
DUX4L7	PRAMEF9	ENSP00000451411	ENSP00000365322	Double homeodomain protein dux4-s; Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	Prame family member 9/15; PRAME family member 9; Belongs to the PRAME family	0.432
DUX4L7	ZSCAN4	ENSP00000451411	ENSP00000321963	Double homeodomain protein dux4-s; Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	Zinc finger and SCAN domain-containing protein 4; Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity); SCAN domain containing	0.711
LRRC8E	PRAMEF11	ENSP00000479953	ENSP00000480027	Volume-regulated anion channel subunit LRRC8E; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition	Prame family member 11; Belongs to the PRAME family	0.454
LRRC8E	PRAMEF4	ENSP00000479953	ENSP00000235349	Volume-regulated anion channel subunit LRRC8E; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition	PRAME family member 4; Belongs to the PRAME family	0.454
LRRC8E	PRAMEF5	ENSP00000479953	ENSP00000480122	Volume-regulated anion channel subunit LRRC8E; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition	PRAME family member 5; Belongs to the PRAME family	0.459
LRRC8E	PRAMEF8	ENSP00000479953	ENSP00000349931	Volume-regulated anion channel subunit LRRC8E; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition	PRAME family member 8; Belongs to the PRAME family	0.412
LRRC8E	PRAMEF9	ENSP00000479953	ENSP00000365322	Volume-regulated anion channel subunit LRRC8E; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition	Prame family member 9/15; PRAME family member 9; Belongs to the PRAME family	0.420
MBD3L2	DUX4L7	ENSP00000370800	ENSP00000451411	methyl-CpG binding domain protein 3 like 2; Belongs to the MBD3L family	Double homeodomain protein dux4-s; Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes	0.612
MBD3L2	PRAMEF11	ENSP00000370800	ENSP00000480027	methyl-CpG binding domain protein 3 like 2; Belongs to the MBD3L family	Prame family member 11; Belongs to the PRAME family	0.591
MBD3L2	PRAMEF4	ENSP00000370800	ENSP00000235349	methyl-CpG binding domain protein 3 like 2; Belongs to the MBD3L family	PRAME family member 4; Belongs to the PRAME family	0.559
MBD3L2	PRAMEF5	ENSP00000370800	ENSP00000480122	methyl-CpG binding domain protein 3 like 2; Belongs to the MBD3L family	PRAME family member 5; Belongs to the PRAME family	0.702