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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRAMEF4PRAME family member 4; Belongs to the PRAME family (478 aa)    
Predicted Functional Partners:
PRAMEF5
PRAME family member 5; Belongs to the PRAME family
   
  
0.694
MBD3L2
methyl-CpG binding domain protein 3 like 2; Belongs to the MBD3L family
   
  
 0.559
PRAMEF11
Prame family member 11; Belongs to the PRAME family
   
   
0.541
PRAMEF8
PRAME family member 8; Belongs to the PRAME family
   
   
0.521
ZSCAN4
Zinc finger and SCAN domain-containing protein 4; Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity); SCAN domain containing
      
 0.469
PRAMEF9
Prame family member 9/15; PRAME family member 9; Belongs to the PRAME family
   
  
0.458
CDH12
Cadherin-12; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types
      
 0.455
ANKRD36C
Ankyrin repeat domain-containing protein 36C; Ankyrin repeat domain containing
      
 0.454
LRRC8E
Volume-regulated anion channel subunit LRRC8E; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition
      
 0.454
DUX4L7
Double homeodomain protein dux4-s; Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes
      
 0.445
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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