node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASB7 | PRDM10 | ENSP00000328327 | ENSP00000351686 | Ankyrin repeat and SOCS box protein 7; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | PR domain zinc finger protein 10; May be involved in transcriptional regulation. | 0.554 |
AVPR2 | PRDM10 | ENSP00000496396 | ENSP00000351686 | Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. | PR domain zinc finger protein 10; May be involved in transcriptional regulation. | 0.504 |
AVPR2 | TOP2A | ENSP00000496396 | ENSP00000411532 | Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. | DNA topoisomerase 2-alpha; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity). | 0.512 |
CITED2 | PRDM10 | ENSP00000444198 | ENSP00000351686 | Cbp/p300-interacting transactivator 2; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts [...] | PR domain zinc finger protein 10; May be involved in transcriptional regulation. | 0.493 |
ENTHD1 | PRDM10 | ENSP00000317431 | ENSP00000351686 | ENTH domain containing 1. | PR domain zinc finger protein 10; May be involved in transcriptional regulation. | 0.503 |
ENTHD1 | SLITRK1 | ENSP00000317431 | ENSP00000366288 | ENTH domain containing 1. | SLIT and NTRK-like protein 1; It is involved in synaptogenesis and promotes excitatory synapse differentiation. Enhances neuronal dendrite outgrowth. | 0.480 |
ENTHD1 | ZNHIT2 | ENSP00000317431 | ENSP00000308548 | ENTH domain containing 1. | Zinc finger HIT domain-containing protein 2; May act as a bridging factor mediating the interaction between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small nuclear ribonucleoprotein (U5 snRNP). Required for the interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit URI1 with U5 snRNP proteins EFTUD2 and PRPF8. May play a role in regulating the composition of the U5 snRNP complex. | 0.531 |
PRDM10 | ASB7 | ENSP00000351686 | ENSP00000328327 | PR domain zinc finger protein 10; May be involved in transcriptional regulation. | Ankyrin repeat and SOCS box protein 7; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family. | 0.554 |
PRDM10 | AVPR2 | ENSP00000351686 | ENSP00000496396 | PR domain zinc finger protein 10; May be involved in transcriptional regulation. | Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. | 0.504 |
PRDM10 | CITED2 | ENSP00000351686 | ENSP00000444198 | PR domain zinc finger protein 10; May be involved in transcriptional regulation. | Cbp/p300-interacting transactivator 2; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts [...] | 0.493 |
PRDM10 | ENTHD1 | ENSP00000351686 | ENSP00000317431 | PR domain zinc finger protein 10; May be involved in transcriptional regulation. | ENTH domain containing 1. | 0.503 |
PRDM10 | PRDM8 | ENSP00000351686 | ENSP00000339764 | PR domain zinc finger protein 10; May be involved in transcriptional regulation. | PR domain zinc finger protein 8; Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity). Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (By similarity). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (By similarity). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (By similarity); Belongs to the class V-like SAM-binding methyltrans [...] | 0.545 |
PRDM10 | SETD4 | ENSP00000351686 | ENSP00000382163 | PR domain zinc finger protein 10; May be involved in transcriptional regulation. | SET domain containing 4; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family. | 0.558 |
PRDM10 | SLITRK1 | ENSP00000351686 | ENSP00000366288 | PR domain zinc finger protein 10; May be involved in transcriptional regulation. | SLIT and NTRK-like protein 1; It is involved in synaptogenesis and promotes excitatory synapse differentiation. Enhances neuronal dendrite outgrowth. | 0.515 |
PRDM10 | TOP2A | ENSP00000351686 | ENSP00000411532 | PR domain zinc finger protein 10; May be involved in transcriptional regulation. | DNA topoisomerase 2-alpha; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity). | 0.602 |
PRDM10 | ZNF510 | ENSP00000351686 | ENSP00000364379 | PR domain zinc finger protein 10; May be involved in transcriptional regulation. | Zinc finger protein 510; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.530 |
PRDM10 | ZNHIT2 | ENSP00000351686 | ENSP00000308548 | PR domain zinc finger protein 10; May be involved in transcriptional regulation. | Zinc finger HIT domain-containing protein 2; May act as a bridging factor mediating the interaction between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small nuclear ribonucleoprotein (U5 snRNP). Required for the interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit URI1 with U5 snRNP proteins EFTUD2 and PRPF8. May play a role in regulating the composition of the U5 snRNP complex. | 0.496 |
PRDM8 | PRDM10 | ENSP00000339764 | ENSP00000351686 | PR domain zinc finger protein 8; Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity). Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (By similarity). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (By similarity). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (By similarity); Belongs to the class V-like SAM-binding methyltrans [...] | PR domain zinc finger protein 10; May be involved in transcriptional regulation. | 0.545 |
SETD4 | PRDM10 | ENSP00000382163 | ENSP00000351686 | SET domain containing 4; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family. | PR domain zinc finger protein 10; May be involved in transcriptional regulation. | 0.558 |
SLITRK1 | ENTHD1 | ENSP00000366288 | ENSP00000317431 | SLIT and NTRK-like protein 1; It is involved in synaptogenesis and promotes excitatory synapse differentiation. Enhances neuronal dendrite outgrowth. | ENTH domain containing 1. | 0.480 |