node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNA1 | PROCA1 | ENSP00000255465 | ENSP00000301039 | Cyclin-A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. Belongs to the cyclin family. Cyclin AB subfamily. | Protein interacting with cyclin A1; Belongs to the PROCA1 family. | 0.602 |
CUL7 | FAU | ENSP00000438788 | ENSP00000431822 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | 0.992 |
CUL7 | MRPL2 | ENSP00000438788 | ENSP00000373404 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family. | 0.451 |
CUL7 | PROCA1 | ENSP00000438788 | ENSP00000301039 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | Protein interacting with cyclin A1; Belongs to the PROCA1 family. | 0.551 |
CUL7 | RPL21 | ENSP00000438788 | ENSP00000346027 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | 60S ribosomal protein L21; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL21 family. | 0.973 |
FAU | CUL7 | ENSP00000431822 | ENSP00000438788 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | 0.992 |
FAU | MRPL2 | ENSP00000431822 | ENSP00000373404 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family. | 0.992 |
FAU | PROCA1 | ENSP00000431822 | ENSP00000301039 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | Protein interacting with cyclin A1; Belongs to the PROCA1 family. | 0.796 |
FAU | RPL21 | ENSP00000431822 | ENSP00000346027 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | 60S ribosomal protein L21; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL21 family. | 0.999 |
FAU | RPL8 | ENSP00000431822 | ENSP00000262584 | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | 60S ribosomal protein L8; Component of the large ribosomal subunit. | 0.999 |
GRPR | PROCA1 | ENSP00000369643 | ENSP00000301039 | Gastrin-releasing peptide receptor; Receptor for gastrin-releasing peptide (GRP). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory (By si [...] | Protein interacting with cyclin A1; Belongs to the PROCA1 family. | 0.614 |
LYRM4 | MRPL2 | ENSP00000443900 | ENSP00000373404 | LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis; Belongs to the complex I LYR family. | Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family. | 0.400 |
LYRM4 | PROCA1 | ENSP00000443900 | ENSP00000301039 | LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis; Belongs to the complex I LYR family. | Protein interacting with cyclin A1; Belongs to the PROCA1 family. | 0.579 |
MRPL2 | CUL7 | ENSP00000373404 | ENSP00000438788 | Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family. | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | 0.451 |
MRPL2 | FAU | ENSP00000373404 | ENSP00000431822 | Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family. | Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion. | 0.992 |
MRPL2 | LYRM4 | ENSP00000373404 | ENSP00000443900 | Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family. | LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis; Belongs to the complex I LYR family. | 0.400 |
MRPL2 | PROCA1 | ENSP00000373404 | ENSP00000301039 | Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family. | Protein interacting with cyclin A1; Belongs to the PROCA1 family. | 0.548 |
MRPL2 | RPL21 | ENSP00000373404 | ENSP00000346027 | Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family. | 60S ribosomal protein L21; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL21 family. | 0.964 |
PPP2R2D | PROCA1 | ENSP00000399970 | ENSP00000301039 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also ma [...] | Protein interacting with cyclin A1; Belongs to the PROCA1 family. | 0.657 |
PPP2R2D | TBC1D22B | ENSP00000399970 | ENSP00000362590 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also ma [...] | TBC1 domain family member 22B; May act as a GTPase-activating protein for Rab family protein(s). | 0.653 |