STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRR32Proline-rich protein 32; Proline rich 32. (298 aa)    
Predicted Functional Partners:
MCTP1
Multiple C2 and transmembrane domain-containing protein 1; Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. Belongs to the MCTP family.
      
 0.526
ACTRT1
Actin-related protein T1; Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression; Belongs to the actin family.
      
 0.523
OR10P1
Olfactory receptor 10P1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
      
 0.505
GLB1L2
Beta-galactosidase-1-like protein 2; Galactosidase beta 1 like 2.
   
  
 0.502
SBK3
Uncharacterized serine/threonine-protein kinase SBK3; SH3 domain binding kinase family member 3; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
      
 0.479
SPANXN4
Sperm protein associated with the nucleus on the X chromosome N4; SPANX family member N4; Belongs to the SPAN-X family.
      
 0.478
SELENOF
Selenoprotein F; May be involved in redox reactions associated with the formation of disulfide bonds (By similarity). May contribute to the quality control of protein folding in the endoplasmic reticulum. May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2.
      
 0.471
LRRC23
Leucine-rich repeat-containing protein 23; Leucine rich repeat containing 23.
      
 0.464
RD3L
Protein RD3-like; Retinal degeneration 3 like.
      
 0.447
ZNF516
Zinc finger protein 516; Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress.
      
 0.444
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.