node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMOTL1 | PRTG | ENSP00000387739 | ENSP00000373937 | Angiomotin-like protein 1; Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus; Belongs to the angiomotin family. | Protogenin; May play a role in anteroposterior axis elongation. Belongs to the immunoglobulin superfamily. DCC family. | 0.412 |
DAZAP2 | PRTG | ENSP00000448051 | ENSP00000373937 | DAZ associated protein 2. | Protogenin; May play a role in anteroposterior axis elongation. Belongs to the immunoglobulin superfamily. DCC family. | 0.480 |
ERICH6B | PRTG | ENSP00000298738 | ENSP00000373937 | Glutamate-rich protein 6B; Glutamate rich 6B. | Protogenin; May play a role in anteroposterior axis elongation. Belongs to the immunoglobulin superfamily. DCC family. | 0.443 |
FCGRT | PRTG | ENSP00000410798 | ENSP00000373937 | IgG receptor FcRn large subunit p51; Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, [...] | Protogenin; May play a role in anteroposterior axis elongation. Belongs to the immunoglobulin superfamily. DCC family. | 0.465 |
LIN28B | PRTG | ENSP00000344401 | ENSP00000373937 | Protein lin-28 homolog B; Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA. Does not act on pri-miR21. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recr [...] | Protogenin; May play a role in anteroposterior axis elongation. Belongs to the immunoglobulin superfamily. DCC family. | 0.418 |
LRFN2 | PRTG | ENSP00000345985 | ENSP00000373937 | Leucine-rich repeat and fibronectin type-III domain-containing protein 2; Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery (By similarity). | Protogenin; May play a role in anteroposterior axis elongation. Belongs to the immunoglobulin superfamily. DCC family. | 0.568 |
LRRC63 | PRTG | ENSP00000469337 | ENSP00000373937 | Leucine-rich repeat-containing protein 63; Leucine rich repeat containing 63. | Protogenin; May play a role in anteroposterior axis elongation. Belongs to the immunoglobulin superfamily. DCC family. | 0.425 |
PRTG | AMOTL1 | ENSP00000373937 | ENSP00000387739 | Protogenin; May play a role in anteroposterior axis elongation. Belongs to the immunoglobulin superfamily. DCC family. | Angiomotin-like protein 1; Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus; Belongs to the angiomotin family. | 0.412 |
PRTG | DAZAP2 | ENSP00000373937 | ENSP00000448051 | Protogenin; May play a role in anteroposterior axis elongation. Belongs to the immunoglobulin superfamily. DCC family. | DAZ associated protein 2. | 0.480 |
PRTG | ERICH6B | ENSP00000373937 | ENSP00000298738 | Protogenin; May play a role in anteroposterior axis elongation. Belongs to the immunoglobulin superfamily. DCC family. | Glutamate-rich protein 6B; Glutamate rich 6B. | 0.443 |
PRTG | FCGRT | ENSP00000373937 | ENSP00000410798 | Protogenin; May play a role in anteroposterior axis elongation. Belongs to the immunoglobulin superfamily. DCC family. | IgG receptor FcRn large subunit p51; Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, [...] | 0.465 |
PRTG | LIN28B | ENSP00000373937 | ENSP00000344401 | Protogenin; May play a role in anteroposterior axis elongation. Belongs to the immunoglobulin superfamily. DCC family. | Protein lin-28 homolog B; Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA. Does not act on pri-miR21. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recr [...] | 0.418 |
PRTG | LRFN2 | ENSP00000373937 | ENSP00000345985 | Protogenin; May play a role in anteroposterior axis elongation. Belongs to the immunoglobulin superfamily. DCC family. | Leucine-rich repeat and fibronectin type-III domain-containing protein 2; Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery (By similarity). | 0.568 |
PRTG | LRRC63 | ENSP00000373937 | ENSP00000469337 | Protogenin; May play a role in anteroposterior axis elongation. Belongs to the immunoglobulin superfamily. DCC family. | Leucine-rich repeat-containing protein 63; Leucine rich repeat containing 63. | 0.425 |