node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALPP | CSH1 | ENSP00000375881 | ENSP00000316416 | Alkaline phosphatase, placental. | Chorionic somatomammotropin hormone 1; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | 0.586 |
ALPP | CSH2 | ENSP00000375881 | ENSP00000376623 | Alkaline phosphatase, placental. | Chorionic somatomammotropin hormone 2; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | 0.574 |
ALPP | PSG11 | ENSP00000375881 | ENSP00000319140 | Alkaline phosphatase, placental. | Pregnancy specific beta-1-glycoprotein 11. | 0.519 |
ALPP | PSG3 | ENSP00000375881 | ENSP00000332215 | Alkaline phosphatase, placental. | Pregnancy specific beta-1-glycoprotein 3; Belongs to the immunoglobulin superfamily. CEA family. | 0.492 |
ALPP | PSG4 | ENSP00000375881 | ENSP00000384770 | Alkaline phosphatase, placental. | Pregnancy specific beta-1-glycoprotein 4. | 0.473 |
CSH1 | ALPP | ENSP00000316416 | ENSP00000375881 | Chorionic somatomammotropin hormone 1; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Alkaline phosphatase, placental. | 0.586 |
CSH1 | CSH2 | ENSP00000316416 | ENSP00000376623 | Chorionic somatomammotropin hormone 1; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Chorionic somatomammotropin hormone 2; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | 0.998 |
CSH1 | PAPPA | ENSP00000316416 | ENSP00000330658 | Chorionic somatomammotropin hormone 1; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Pappalysin-1; Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family. | 0.592 |
CSH1 | PSG11 | ENSP00000316416 | ENSP00000319140 | Chorionic somatomammotropin hormone 1; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Pregnancy specific beta-1-glycoprotein 11. | 0.804 |
CSH1 | PSG3 | ENSP00000316416 | ENSP00000332215 | Chorionic somatomammotropin hormone 1; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Pregnancy specific beta-1-glycoprotein 3; Belongs to the immunoglobulin superfamily. CEA family. | 0.788 |
CSH1 | PSG4 | ENSP00000316416 | ENSP00000384770 | Chorionic somatomammotropin hormone 1; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Pregnancy specific beta-1-glycoprotein 4. | 0.772 |
CSH2 | ALPP | ENSP00000376623 | ENSP00000375881 | Chorionic somatomammotropin hormone 2; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Alkaline phosphatase, placental. | 0.574 |
CSH2 | CSH1 | ENSP00000376623 | ENSP00000316416 | Chorionic somatomammotropin hormone 2; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Chorionic somatomammotropin hormone 1; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | 0.998 |
CSH2 | PAPPA | ENSP00000376623 | ENSP00000330658 | Chorionic somatomammotropin hormone 2; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Pappalysin-1; Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family. | 0.590 |
CSH2 | PSG11 | ENSP00000376623 | ENSP00000319140 | Chorionic somatomammotropin hormone 2; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Pregnancy specific beta-1-glycoprotein 11. | 0.804 |
CSH2 | PSG3 | ENSP00000376623 | ENSP00000332215 | Chorionic somatomammotropin hormone 2; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Pregnancy specific beta-1-glycoprotein 3; Belongs to the immunoglobulin superfamily. CEA family. | 0.783 |
CSH2 | PSG4 | ENSP00000376623 | ENSP00000384770 | Chorionic somatomammotropin hormone 2; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. | Pregnancy specific beta-1-glycoprotein 4. | 0.771 |
GPC1 | PSG11 | ENSP00000264039 | ENSP00000319140 | Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting th [...] | Pregnancy specific beta-1-glycoprotein 11. | 0.567 |
GPC1 | PSG3 | ENSP00000264039 | ENSP00000332215 | Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting th [...] | Pregnancy specific beta-1-glycoprotein 3; Belongs to the immunoglobulin superfamily. CEA family. | 0.505 |
GPC1 | PSG4 | ENSP00000264039 | ENSP00000384770 | Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting th [...] | Pregnancy specific beta-1-glycoprotein 4. | 0.517 |