node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNNM1 | NIPAL1 | ENSP00000349147 | ENSP00000295461 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Magnesium transporter NIPA3; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). Belongs to the NIPA family. | 0.494 |
CNNM1 | NIPAL3 | ENSP00000349147 | ENSP00000363520 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | NIPA-like protein 3; NIPA like domain containing 3. | 0.519 |
CNNM1 | PTP4A1 | ENSP00000349147 | ENSP00000497588 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. | 0.734 |
CNNM1 | PTP4A2 | ENSP00000349147 | ENSP00000493688 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family. | Protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. | 0.786 |
CNNM2 | NIPAL1 | ENSP00000358894 | ENSP00000295461 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | Magnesium transporter NIPA3; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). Belongs to the NIPA family. | 0.740 |
CNNM2 | NIPAL3 | ENSP00000358894 | ENSP00000363520 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | NIPA-like protein 3; NIPA like domain containing 3. | 0.619 |
CNNM2 | PTP4A1 | ENSP00000358894 | ENSP00000497588 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. | 0.970 |
CNNM2 | PTP4A2 | ENSP00000358894 | ENSP00000493688 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | Protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. | 0.795 |
CNNM3 | CNNM4 | ENSP00000305449 | ENSP00000366275 | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | Metal transporter CNNM4; Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. | 0.419 |
CNNM3 | NIPAL1 | ENSP00000305449 | ENSP00000295461 | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | Magnesium transporter NIPA3; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). Belongs to the NIPA family. | 0.593 |
CNNM3 | NIPAL3 | ENSP00000305449 | ENSP00000363520 | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | NIPA-like protein 3; NIPA like domain containing 3. | 0.606 |
CNNM3 | PTP4A1 | ENSP00000305449 | ENSP00000497588 | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. | 0.798 |
CNNM3 | PTP4A2 | ENSP00000305449 | ENSP00000493688 | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | Protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. | 0.998 |
CNNM4 | CNNM3 | ENSP00000366275 | ENSP00000305449 | Metal transporter CNNM4; Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family. | 0.419 |
CNNM4 | NIPAL1 | ENSP00000366275 | ENSP00000295461 | Metal transporter CNNM4; Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. | Magnesium transporter NIPA3; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). Belongs to the NIPA family. | 0.554 |
CNNM4 | NIPAL3 | ENSP00000366275 | ENSP00000363520 | Metal transporter CNNM4; Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. | NIPA-like protein 3; NIPA like domain containing 3. | 0.583 |
CNNM4 | PTP4A1 | ENSP00000366275 | ENSP00000497588 | Metal transporter CNNM4; Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. | Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. | 0.737 |
CNNM4 | PTP4A2 | ENSP00000366275 | ENSP00000493688 | Metal transporter CNNM4; Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. | Protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. | 0.799 |
IL17RD | PTP4A1 | ENSP00000296318 | ENSP00000497588 | Interleukin-17 receptor D; Feedback inhibitor of fibroblast growth factor mediated Ras- MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity). | Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. | 0.768 |
IL17RD | PTP4A2 | ENSP00000296318 | ENSP00000493688 | Interleukin-17 receptor D; Feedback inhibitor of fibroblast growth factor mediated Ras- MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity). | Protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. | 0.777 |