node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC183 | RABL6 | ENSP00000338013 | ENSP00000360727 | Coiled-coil domain containing 183. | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. | 0.658 |
CDKN2A | CDKN2AIP | ENSP00000418915 | ENSP00000427108 | Cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. | CDKN2A-interacting protein; Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence; Belongs to the CARF family. | 0.958 |
CDKN2A | RABL6 | ENSP00000418915 | ENSP00000360727 | Cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. | 0.654 |
CDKN2A | TBRG1 | ENSP00000418915 | ENSP00000409016 | Cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. | Transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability; Belongs to the TBRG1 family. | 0.542 |
CDKN2AIP | CDKN2A | ENSP00000427108 | ENSP00000418915 | CDKN2A-interacting protein; Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence; Belongs to the CARF family. | Cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. | 0.958 |
CDKN2AIP | RABL6 | ENSP00000427108 | ENSP00000360727 | CDKN2A-interacting protein; Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence; Belongs to the CARF family. | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. | 0.629 |
MBD3 | RABL6 | ENSP00000412302 | ENSP00000360727 | Methyl-CpG-binding domain protein 3; Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides. Recruits histone deacetylases and DNA methyltransferases. | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. | 0.769 |
RABL3 | RABL6 | ENSP00000273375 | ENSP00000360727 | Rab-like protein 3; RAB, member of RAS oncogene family like 3; Belongs to the small GTPase superfamily. Rab family. | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. | 0.571 |
RABL6 | CCDC183 | ENSP00000360727 | ENSP00000338013 | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. | Coiled-coil domain containing 183. | 0.658 |
RABL6 | CDKN2A | ENSP00000360727 | ENSP00000418915 | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. | Cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. | 0.654 |
RABL6 | CDKN2AIP | ENSP00000360727 | ENSP00000427108 | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. | CDKN2A-interacting protein; Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence; Belongs to the CARF family. | 0.629 |
RABL6 | MBD3 | ENSP00000360727 | ENSP00000412302 | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. | Methyl-CpG-binding domain protein 3; Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides. Recruits histone deacetylases and DNA methyltransferases. | 0.769 |
RABL6 | RABL3 | ENSP00000360727 | ENSP00000273375 | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. | Rab-like protein 3; RAB, member of RAS oncogene family like 3; Belongs to the small GTPase superfamily. Rab family. | 0.571 |
RABL6 | SPINK7 | ENSP00000360727 | ENSP00000274565 | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. | Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor. | 0.579 |
RABL6 | TBRG1 | ENSP00000360727 | ENSP00000409016 | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. | Transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability; Belongs to the TBRG1 family. | 0.774 |
RABL6 | TRAPPC1 | ENSP00000360727 | ENSP00000302783 | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. | Trafficking protein particle complex subunit 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET5 subfamily. | 0.559 |
RABL6 | VPS33A | ENSP00000360727 | ENSP00000267199 | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. | Vacuolar protein sorting-associated protein 33A; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosom [...] | 0.579 |
RABL6 | VPS33B | ENSP00000360727 | ENSP00000327650 | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. | Vacuolar protein sorting-associated protein 33B; May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity. Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesic [...] | 0.606 |
SPINK7 | RABL6 | ENSP00000274565 | ENSP00000360727 | Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor. | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. | 0.579 |
TBRG1 | CDKN2A | ENSP00000409016 | ENSP00000418915 | Transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability; Belongs to the TBRG1 family. | Cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. | 0.542 |