node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARMC7 | CRIPT | ENSP00000245543 | ENSP00000238892 | Armadillo repeat containing 7. | Cysteine-rich PDZ-binding protein; Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. | 0.942 |
ARMC7 | CWC27 | ENSP00000245543 | ENSP00000370460 | Armadillo repeat containing 7. | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. | 0.922 |
ARMC7 | EFTUD2 | ENSP00000245543 | ENSP00000392094 | Armadillo repeat containing 7. | 116 kDa U5 small nuclear ribonucleoprotein component; Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | 0.923 |
ARMC7 | PPIL2 | ENSP00000245543 | ENSP00000486725 | Armadillo repeat containing 7. | RING-type E3 ubiquitin-protein ligase PPIL2; Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'- linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl- prolyl cis-trans isomerase activity. Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily. | 0.943 |
ARMC7 | PRPF8 | ENSP00000245543 | ENSP00000460348 | Armadillo repeat containing 7. | Pre-mRNA-processing-splicing factor 8; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both t [...] | 0.922 |
ARMC7 | RBM48 | ENSP00000245543 | ENSP00000265732 | Armadillo repeat containing 7. | RNA binding motif protein 48; Belongs to the RBM48 family. | 0.996 |
ARMC7 | RNF113A | ENSP00000245543 | ENSP00000360497 | Armadillo repeat containing 7. | E3 ubiquitin-protein ligase RNF113A; Required for pre-mRNA splicing as component of the spliceosome. E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents. Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling. | 0.924 |
ARMC7 | SCNM1 | ENSP00000245543 | ENSP00000357901 | Armadillo repeat containing 7. | Sodium channel modifier 1; Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites. | 0.949 |
ARMC7 | SNIP1 | ENSP00000245543 | ENSP00000296215 | Armadillo repeat containing 7. | Smad nuclear-interacting protein 1; Required for pre-mRNA splicing as component of the spliceosome. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. | 0.922 |
ARMC7 | SNRNP40 | ENSP00000245543 | ENSP00000263694 | Armadillo repeat containing 7. | U5 small nuclear ribonucleoprotein 40 kDa protein; Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. | 0.922 |
CRIPT | ARMC7 | ENSP00000238892 | ENSP00000245543 | Cysteine-rich PDZ-binding protein; Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. | Armadillo repeat containing 7. | 0.942 |
CRIPT | CWC27 | ENSP00000238892 | ENSP00000370460 | Cysteine-rich PDZ-binding protein; Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. | Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. | 0.805 |
CRIPT | EFTUD2 | ENSP00000238892 | ENSP00000392094 | Cysteine-rich PDZ-binding protein; Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. | 116 kDa U5 small nuclear ribonucleoprotein component; Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | 0.800 |
CRIPT | PPIL2 | ENSP00000238892 | ENSP00000486725 | Cysteine-rich PDZ-binding protein; Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. | RING-type E3 ubiquitin-protein ligase PPIL2; Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'- linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl- prolyl cis-trans isomerase activity. Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily. | 0.851 |
CRIPT | PRPF8 | ENSP00000238892 | ENSP00000460348 | Cysteine-rich PDZ-binding protein; Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. | Pre-mRNA-processing-splicing factor 8; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both t [...] | 0.900 |
CRIPT | RBM48 | ENSP00000238892 | ENSP00000265732 | Cysteine-rich PDZ-binding protein; Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. | RNA binding motif protein 48; Belongs to the RBM48 family. | 0.865 |
CRIPT | RNF113A | ENSP00000238892 | ENSP00000360497 | Cysteine-rich PDZ-binding protein; Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. | E3 ubiquitin-protein ligase RNF113A; Required for pre-mRNA splicing as component of the spliceosome. E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents. Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling. | 0.900 |
CRIPT | SCNM1 | ENSP00000238892 | ENSP00000357901 | Cysteine-rich PDZ-binding protein; Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. | Sodium channel modifier 1; Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites. | 0.854 |
CRIPT | SNIP1 | ENSP00000238892 | ENSP00000296215 | Cysteine-rich PDZ-binding protein; Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. | Smad nuclear-interacting protein 1; Required for pre-mRNA splicing as component of the spliceosome. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. | 0.800 |
CRIPT | SNRNP40 | ENSP00000238892 | ENSP00000263694 | Cysteine-rich PDZ-binding protein; Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. | U5 small nuclear ribonucleoprotein 40 kDa protein; Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. | 0.800 |