STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RFPL2Ret finger protein like 2. (378 aa)    
Predicted Functional Partners:
RFPL3
Ret finger protein-like 3; (Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex.
  
 
0.742
PAX6
Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes; Belongs to the paired homeobox family.
    
 
 0.648
PRAMEF1
PRAME family member 1; Belongs to the PRAME family.
   
 
 0.640
PRAMEF13
PRAME family member 13; Belongs to the PRAME family.
   
 
 0.569
PRAMEF11
PRAME family member 11; Belongs to the PRAME family.
   
 
 0.551
PRAMEF2
PRAME family member 2; Belongs to the PRAME family.
   
 
 0.546
PRAMEF12
PRAME family member 12; Belongs to the PRAME family.
   
 
 0.546
ZSCAN4
Zinc finger and SCAN domain-containing protein 4; Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).
   
 
 0.539
MBD3L2
methyl-CpG binding domain protein 3 like 2; Belongs to the MBD3L family.
      
 0.518
PRAMEF25
PRAME family member 25; Belongs to the PRAME family.
   
 
 0.518
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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