node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PANK2 | RNF24 | ENSP00000313377 | ENSP00000388550 | Pantothenate kinase 2, mitochondrial; May be the master regulator of the CoA biosynthesis. Belongs to the type II pantothenate kinase family. | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | 0.592 |
PCED1A | RNF24 | ENSP00000353868 | ENSP00000388550 | PC-esterase domain containing 1A; Belongs to the PC-esterase family. | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | 0.499 |
RNF24 | PANK2 | ENSP00000388550 | ENSP00000313377 | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | Pantothenate kinase 2, mitochondrial; May be the master regulator of the CoA biosynthesis. Belongs to the type II pantothenate kinase family. | 0.592 |
RNF24 | PCED1A | ENSP00000388550 | ENSP00000353868 | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | PC-esterase domain containing 1A; Belongs to the PC-esterase family. | 0.499 |
RNF24 | RWDD1 | ENSP00000388550 | ENSP00000420357 | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | RWD domain-containing protein 1; Protects DRG2 from proteolytic degradation; Belongs to the RWDD1/GIR2 family. | 0.499 |
RNF24 | TRPC1 | ENSP00000388550 | ENSP00000419313 | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | Short transient receptor potential channel 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. | 0.605 |
RNF24 | TRPC3 | ENSP00000388550 | ENSP00000368966 | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | Short transient receptor potential channel 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. | 0.637 |
RNF24 | TRPC4 | ENSP00000388550 | ENSP00000486109 | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | Short transient receptor potential channel 4; Forms a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily. | 0.691 |
RNF24 | TRPC5 | ENSP00000388550 | ENSP00000262839 | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | Short transient receptor potential channel 5; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. | 0.688 |
RNF24 | TRPC6 | ENSP00000388550 | ENSP00000340913 | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | Short transient receptor potential channel 6; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. | 0.892 |
RNF24 | TRPM2 | ENSP00000388550 | ENSP00000381026 | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | Transient receptor potential cation channel subfamily M member 2; [Isoform 1]: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP- ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. Extracellular calcium passes through the channel and increases channel activity. Contributes to Ca(2+) release from intracellular stores in response to ADP-ribose. Plays [...] | 0.658 |
RNF24 | UBOX5 | ENSP00000388550 | ENSP00000217173 | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | RING finger protein 37; May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. | 0.479 |
RWDD1 | RNF24 | ENSP00000420357 | ENSP00000388550 | RWD domain-containing protein 1; Protects DRG2 from proteolytic degradation; Belongs to the RWDD1/GIR2 family. | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | 0.499 |
TRPC1 | RNF24 | ENSP00000419313 | ENSP00000388550 | Short transient receptor potential channel 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | 0.605 |
TRPC1 | TRPC3 | ENSP00000419313 | ENSP00000368966 | Short transient receptor potential channel 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. | Short transient receptor potential channel 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. | 0.981 |
TRPC1 | TRPC4 | ENSP00000419313 | ENSP00000486109 | Short transient receptor potential channel 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. | Short transient receptor potential channel 4; Forms a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily. | 0.999 |
TRPC1 | TRPC5 | ENSP00000419313 | ENSP00000262839 | Short transient receptor potential channel 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. | Short transient receptor potential channel 5; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. | 0.999 |
TRPC1 | TRPC6 | ENSP00000419313 | ENSP00000340913 | Short transient receptor potential channel 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. | Short transient receptor potential channel 6; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. | 0.939 |
TRPC1 | TRPM2 | ENSP00000419313 | ENSP00000381026 | Short transient receptor potential channel 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. | Transient receptor potential cation channel subfamily M member 2; [Isoform 1]: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP- ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. Extracellular calcium passes through the channel and increases channel activity. Contributes to Ca(2+) release from intracellular stores in response to ADP-ribose. Plays [...] | 0.499 |
TRPC3 | RNF24 | ENSP00000368966 | ENSP00000388550 | Short transient receptor potential channel 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. | RING finger protein 24; May play a role in TRPCs intracellular trafficking. | 0.637 |