node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRIX1 | EBNA1BP2 | ENSP00000338862 | ENSP00000407323 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | 0.999 |
BRIX1 | GTPBP4 | ENSP00000338862 | ENSP00000354040 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. | 0.998 |
BRIX1 | NIFK | ENSP00000338862 | ENSP00000285814 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Nucleolar protein interacting with the FHA domain of MKI67. | 0.999 |
BRIX1 | PUM3 | ENSP00000338862 | ENSP00000380982 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity). | 0.988 |
BRIX1 | RBM28 | ENSP00000338862 | ENSP00000223073 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | RNA-binding protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes. | 0.948 |
BRIX1 | RPF2 | ENSP00000338862 | ENSP00000402338 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. | 0.993 |
BRIX1 | RRP8 | ENSP00000338862 | ENSP00000254605 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] | 0.920 |
EBNA1BP2 | BRIX1 | ENSP00000407323 | ENSP00000338862 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | 0.999 |
EBNA1BP2 | GTPBP4 | ENSP00000407323 | ENSP00000354040 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. | 0.997 |
EBNA1BP2 | NIFK | ENSP00000407323 | ENSP00000285814 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | Nucleolar protein interacting with the FHA domain of MKI67. | 0.999 |
EBNA1BP2 | PUM3 | ENSP00000407323 | ENSP00000380982 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity). | 0.995 |
EBNA1BP2 | RBM28 | ENSP00000407323 | ENSP00000223073 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | RNA-binding protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes. | 0.972 |
EBNA1BP2 | RPF2 | ENSP00000407323 | ENSP00000402338 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. | 0.999 |
EBNA1BP2 | RRP8 | ENSP00000407323 | ENSP00000254605 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] | 0.920 |
GTPBP4 | BRIX1 | ENSP00000354040 | ENSP00000338862 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. | 0.998 |
GTPBP4 | EBNA1BP2 | ENSP00000354040 | ENSP00000407323 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA. | 0.997 |
GTPBP4 | NIFK | ENSP00000354040 | ENSP00000285814 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. | Nucleolar protein interacting with the FHA domain of MKI67. | 0.998 |
GTPBP4 | PUM3 | ENSP00000354040 | ENSP00000380982 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. | Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells (By similarity). | 0.990 |
GTPBP4 | RBM28 | ENSP00000354040 | ENSP00000223073 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. | RNA-binding protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes. | 0.975 |
GTPBP4 | RPF2 | ENSP00000354040 | ENSP00000402338 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. | 0.999 |