node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLLU1OS | RTL8C | ENSP00000367748 | ENSP00000257013 | Putative chronic lymphocytic leukemia up-regulated protein 1 opposite strand transcript protein. | Retrotransposon Gag like 8C; Belongs to the FAM127 family. | 0.433 |
FANCM | PEG10 | ENSP00000267430 | ENSP00000418944 | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | Retrotransposon-derived protein PEG10; Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'- GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein ( [...] | 0.536 |
FANCM | RTL4 | ENSP00000267430 | ENSP00000340590 | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | Retrotransposon Gag-like protein 4; Involved in cognitive function in the brain, possibly via the noradrenergic system. | 0.532 |
FANCM | RTL5 | ENSP00000267430 | ENSP00000476792 | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | Retrotransposon Gag like 5. | 0.532 |
FANCM | RTL8A | ENSP00000267430 | ENSP00000375267 | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | Retrotransposon Gag like 8A; Belongs to the FAM127 family. | 0.532 |
FANCM | RTL8C | ENSP00000267430 | ENSP00000257013 | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | Retrotransposon Gag like 8C; Belongs to the FAM127 family. | 0.532 |
FANCM | RTL9 | ENSP00000267430 | ENSP00000419786 | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | Retrotransposon Gag like 9. | 0.532 |
PEG10 | FANCM | ENSP00000418944 | ENSP00000267430 | Retrotransposon-derived protein PEG10; Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'- GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein ( [...] | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | 0.536 |
PEG10 | RTL4 | ENSP00000418944 | ENSP00000340590 | Retrotransposon-derived protein PEG10; Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'- GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein ( [...] | Retrotransposon Gag-like protein 4; Involved in cognitive function in the brain, possibly via the noradrenergic system. | 0.419 |
PEG10 | RTL8A | ENSP00000418944 | ENSP00000375267 | Retrotransposon-derived protein PEG10; Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'- GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein ( [...] | Retrotransposon Gag like 8A; Belongs to the FAM127 family. | 0.810 |
PEG10 | RTL8C | ENSP00000418944 | ENSP00000257013 | Retrotransposon-derived protein PEG10; Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'- GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein ( [...] | Retrotransposon Gag like 8C; Belongs to the FAM127 family. | 0.807 |
RTL4 | FANCM | ENSP00000340590 | ENSP00000267430 | Retrotransposon Gag-like protein 4; Involved in cognitive function in the brain, possibly via the noradrenergic system. | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | 0.532 |
RTL4 | PEG10 | ENSP00000340590 | ENSP00000418944 | Retrotransposon Gag-like protein 4; Involved in cognitive function in the brain, possibly via the noradrenergic system. | Retrotransposon-derived protein PEG10; Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'- GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein ( [...] | 0.419 |
RTL4 | RTL5 | ENSP00000340590 | ENSP00000476792 | Retrotransposon Gag-like protein 4; Involved in cognitive function in the brain, possibly via the noradrenergic system. | Retrotransposon Gag like 5. | 0.518 |
RTL4 | RTL8C | ENSP00000340590 | ENSP00000257013 | Retrotransposon Gag-like protein 4; Involved in cognitive function in the brain, possibly via the noradrenergic system. | Retrotransposon Gag like 8C; Belongs to the FAM127 family. | 0.674 |
RTL4 | RTL9 | ENSP00000340590 | ENSP00000419786 | Retrotransposon Gag-like protein 4; Involved in cognitive function in the brain, possibly via the noradrenergic system. | Retrotransposon Gag like 9. | 0.716 |
RTL5 | FANCM | ENSP00000476792 | ENSP00000267430 | Retrotransposon Gag like 5. | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross- linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork- structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This acti [...] | 0.532 |
RTL5 | RTL4 | ENSP00000476792 | ENSP00000340590 | Retrotransposon Gag like 5. | Retrotransposon Gag-like protein 4; Involved in cognitive function in the brain, possibly via the noradrenergic system. | 0.518 |
RTL5 | RTL8A | ENSP00000476792 | ENSP00000375267 | Retrotransposon Gag like 5. | Retrotransposon Gag like 8A; Belongs to the FAM127 family. | 0.528 |
RTL5 | RTL8C | ENSP00000476792 | ENSP00000257013 | Retrotransposon Gag like 5. | Retrotransposon Gag like 8C; Belongs to the FAM127 family. | 0.681 |