STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RWDD2ARWD domain containing 2A. (292 aa)    
Predicted Functional Partners:
RWDD1
RWD domain-containing protein 1; Protects DRG2 from proteolytic degradation; Belongs to the RWDD1/GIR2 family.
   
  
 0.675
C11orf71
Uncharacterized protein C11orf71; Chromosome 11 open reading frame 71.
   
  
 0.565
PGM3
Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation.
   
  
 0.556
KIAA1755
Uncharacterized protein KIAA1755; KIAA1755.
      
 0.484
RWDD4
RWD domain containing 4.
   
  
 0.482
C6orf163
Uncharacterized protein C6orf163; Chromosome 6 open reading frame 163.
      
 0.480
ZBTB47
Zinc finger and BTB domain-containing protein 47; May be involved in transcriptional regulation.
      
 0.476
MEAK7
MTOR-associated protein MEAK7; Activates an alternative mTOR signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration. Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome.
      
 0.466
C22orf39
UPF0545 protein C22orf39; Chromosome 22 open reading frame 39; Belongs to the UPF0545 family.
      
 0.463
ATG7
Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]
    
 
 0.461
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: medium (80%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.