SBSPON protein (human) - STRING interaction network

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SBSPON

Somatomedin-B and thrombospondin type-1 domain-containing protein; Somatomedin B and thrombospondin type 1 domain containing; Belongs to the thrombospondin family (264 aa)

Predicted Functional Partners:

ADAMTS9

0.913

SEMA5A

0.909

ADAMTS1

0.908

ADAMTS3

0.906

ADAMTS4

0.905

ADAMTSL4

0.905

ADAMTSL3

0.903

ADAMTS17

0.902

ADAMTS16

0.902

ADAMTS18

0.902

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS1	ADAMTS16	ENSP00000284984	ENSP00000274181	A disintegrin and metalloproteinase with thrombospondin motifs 1; Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-\|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture; ADAM metallopeptidases with thrombospondin type 1 motif	A disintegrin and metalloproteinase with thrombospondin motifs 16; ADAM metallopeptidase with thrombospondin type 1 motif 16	0.916
ADAMTS1	ADAMTS17	ENSP00000284984	ENSP00000268070	A disintegrin and metalloproteinase with thrombospondin motifs 1; Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-\|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture; ADAM metallopeptidases with thrombospondin type 1 motif	A disintegrin and metalloproteinase with thrombospondin motifs 17; ADAM metallopeptidase with thrombospondin type 1 motif 17	0.916
ADAMTS1	ADAMTS18	ENSP00000284984	ENSP00000282849	A disintegrin and metalloproteinase with thrombospondin motifs 1; Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-\|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture; ADAM metallopeptidases with thrombospondin type 1 motif	A disintegrin and metalloproteinase with thrombospondin motifs 18; ADAM metallopeptidase with thrombospondin type 1 motif 18	0.914
ADAMTS1	ADAMTS3	ENSP00000284984	ENSP00000286657	A disintegrin and metalloproteinase with thrombospondin motifs 1; Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-\|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture; ADAM metallopeptidases with thrombospondin type 1 motif	A disintegrin and metalloproteinase with thrombospondin motifs 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens; ADAM metallopeptidases with thrombospondin type 1 motif	0.922
ADAMTS1	ADAMTS4	ENSP00000284984	ENSP00000356975	A disintegrin and metalloproteinase with thrombospondin motifs 1; Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-\|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture; ADAM metallopeptidases with thrombospondin type 1 motif	A disintegrin and metalloproteinase with thrombospondin motifs 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-\|-Ala-393' site; ADAM metallopeptidases with thrombospondin type 1 motif	0.907
ADAMTS1	ADAMTS9	ENSP00000284984	ENSP00000418735	A disintegrin and metalloproteinase with thrombospondin motifs 1; Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-\|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture; ADAM metallopeptidases with thrombospondin type 1 motif	A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-\|-Ala-1839' site) and versican (at the '1428- Glu-\|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos; ADAM metallopeptidases with thrombospondin type 1 motif	0.913
ADAMTS1	ADAMTSL3	ENSP00000284984	ENSP00000286744	A disintegrin and metalloproteinase with thrombospondin motifs 1; Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-\|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture; ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS-like protein 3; Immunoglobulin like domain containing	0.927
ADAMTS1	ADAMTSL4	ENSP00000284984	ENSP00000358035	A disintegrin and metalloproteinase with thrombospondin motifs 1; Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-\|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture; ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS-like protein 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis; ADAMTS like	0.918
ADAMTS1	SBSPON	ENSP00000284984	ENSP00000297354	A disintegrin and metalloproteinase with thrombospondin motifs 1; Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-\|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture; ADAM metallopeptidases with thrombospondin type 1 motif	Somatomedin-B and thrombospondin type-1 domain-containing protein; Somatomedin B and thrombospondin type 1 domain containing; Belongs to the thrombospondin family	0.908
ADAMTS1	SEMA5A	ENSP00000284984	ENSP00000371936	A disintegrin and metalloproteinase with thrombospondin motifs 1; Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-\|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture; ADAM metallopeptidases with thrombospondin type 1 motif	Semaphorin-5A; Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis [...]	0.910
ADAMTS16	ADAMTS1	ENSP00000274181	ENSP00000284984	A disintegrin and metalloproteinase with thrombospondin motifs 16; ADAM metallopeptidase with thrombospondin type 1 motif 16	A disintegrin and metalloproteinase with thrombospondin motifs 1; Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-\|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture; ADAM metallopeptidases with thrombospondin type 1 motif	0.916
ADAMTS16	ADAMTS17	ENSP00000274181	ENSP00000268070	A disintegrin and metalloproteinase with thrombospondin motifs 16; ADAM metallopeptidase with thrombospondin type 1 motif 16	A disintegrin and metalloproteinase with thrombospondin motifs 17; ADAM metallopeptidase with thrombospondin type 1 motif 17	0.916
ADAMTS16	ADAMTS18	ENSP00000274181	ENSP00000282849	A disintegrin and metalloproteinase with thrombospondin motifs 16; ADAM metallopeptidase with thrombospondin type 1 motif 16	A disintegrin and metalloproteinase with thrombospondin motifs 18; ADAM metallopeptidase with thrombospondin type 1 motif 18	0.906
ADAMTS16	ADAMTS3	ENSP00000274181	ENSP00000286657	A disintegrin and metalloproteinase with thrombospondin motifs 16; ADAM metallopeptidase with thrombospondin type 1 motif 16	A disintegrin and metalloproteinase with thrombospondin motifs 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens; ADAM metallopeptidases with thrombospondin type 1 motif	0.913
ADAMTS16	ADAMTS4	ENSP00000274181	ENSP00000356975	A disintegrin and metalloproteinase with thrombospondin motifs 16; ADAM metallopeptidase with thrombospondin type 1 motif 16	A disintegrin and metalloproteinase with thrombospondin motifs 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-\|-Ala-393' site; ADAM metallopeptidases with thrombospondin type 1 motif	0.915
ADAMTS16	ADAMTS9	ENSP00000274181	ENSP00000418735	A disintegrin and metalloproteinase with thrombospondin motifs 16; ADAM metallopeptidase with thrombospondin type 1 motif 16	A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-\|-Ala-1839' site) and versican (at the '1428- Glu-\|-Ala-1429' site). Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos; ADAM metallopeptidases with thrombospondin type 1 motif	0.915
ADAMTS16	ADAMTSL3	ENSP00000274181	ENSP00000286744	A disintegrin and metalloproteinase with thrombospondin motifs 16; ADAM metallopeptidase with thrombospondin type 1 motif 16	ADAMTS-like protein 3; Immunoglobulin like domain containing	0.924
ADAMTS16	ADAMTSL4	ENSP00000274181	ENSP00000358035	A disintegrin and metalloproteinase with thrombospondin motifs 16; ADAM metallopeptidase with thrombospondin type 1 motif 16	ADAMTS-like protein 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis; ADAMTS like	0.905
ADAMTS16	SBSPON	ENSP00000274181	ENSP00000297354	A disintegrin and metalloproteinase with thrombospondin motifs 16; ADAM metallopeptidase with thrombospondin type 1 motif 16	Somatomedin-B and thrombospondin type-1 domain-containing protein; Somatomedin B and thrombospondin type 1 domain containing; Belongs to the thrombospondin family	0.902
ADAMTS16	SEMA5A	ENSP00000274181	ENSP00000371936	A disintegrin and metalloproteinase with thrombospondin motifs 16; ADAM metallopeptidase with thrombospondin type 1 motif 16	Semaphorin-5A; Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis [...]	0.906

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