STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDR39U1Epimerase family protein SDR39U1; Putative NADP-dependent oxidoreductase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily. (293 aa)    
Predicted Functional Partners:
STOML1
Stomatin-like protein 1; May play a role in cholesterol transfer to late endosomes. May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions (By similarity). May play a role in protecting FBXW7 isoform 3 from degradation ; Belongs to the band 7/mec-2 family.
  
  
 0.616
NYNRIN
Protein NYNRIN; NYN domain and retroviral integrase containing.
      
 0.588
TRMT2A
tRNA (uracil-5-)-methyltransferase homolog A; May be involved in nucleic acid metabolism and/or modifications; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
  
  
 0.581
GIMAP7
GTPase IMAP family member 7; The dimer has GTPase activity; the active site contains residues from both subunits.
   
  
 0.564
TUBGCP6
Gamma-tubulin complex component 6; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
   
  
 0.547
STXBP6
Syntaxin-binding protein 6; Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.
      
 0.512
CBLN3
Cerebellin-3; May be involved in synaptic functions in the CNS.
      
 0.510
NCLN
Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning; Belongs to the nicastrin family.
   
  
 0.491
FECH
Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX; Belongs to the ferrochelatase family.
  
  
 0.483
FCGR1B
High affinity immunoglobulin gamma Fc receptor IB; May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response.
      
 0.446
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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