node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABLIM2 | AFAP1 | ENSP00000393511 | ENSP00000410689 | Actin-binding LIM protein 2; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. | Actin filament-associated protein 1; Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. | 0.556 |
ABLIM2 | SH3TC1 | ENSP00000393511 | ENSP00000245105 | Actin-binding LIM protein 2; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. | SH3 domain and tetratricopeptide repeats 1. | 0.495 |
ABLIM2 | SORCS2 | ENSP00000393511 | ENSP00000422185 | Actin-binding LIM protein 2; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. | VPS10 domain-containing receptor SorCS2; The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro). Plays a role in the regulation of dendritic spine density in hippocampus neurons (By similarity). Required for normal neurite branching and extension in response to BDNF. Plays a role in BDNF-dependent hippocampal synaptic plasticity. Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term poten [...] | 0.455 |
AFAP1 | ABLIM2 | ENSP00000410689 | ENSP00000393511 | Actin filament-associated protein 1; Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. | Actin-binding LIM protein 2; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. | 0.556 |
AFAP1 | SH3TC1 | ENSP00000410689 | ENSP00000245105 | Actin filament-associated protein 1; Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. | SH3 domain and tetratricopeptide repeats 1. | 0.537 |
EMSY | SH3TC1 | ENSP00000433205 | ENSP00000245105 | BRCA2-interacting transcriptional repressor EMSY; Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may mediate ligand- dependent transcriptional activation by nuclear hormone receptors. | SH3 domain and tetratricopeptide repeats 1. | 0.428 |
GLT8D1 | SH3TC1 | ENSP00000266014 | ENSP00000245105 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family. | SH3 domain and tetratricopeptide repeats 1. | 0.498 |
HCFC1R1 | SH3TC1 | ENSP00000248089 | ENSP00000245105 | Host cell factor C1 regulator 1; Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus. | SH3 domain and tetratricopeptide repeats 1. | 0.428 |
SH3TC1 | ABLIM2 | ENSP00000245105 | ENSP00000393511 | SH3 domain and tetratricopeptide repeats 1. | Actin-binding LIM protein 2; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. | 0.495 |
SH3TC1 | AFAP1 | ENSP00000245105 | ENSP00000410689 | SH3 domain and tetratricopeptide repeats 1. | Actin filament-associated protein 1; Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. | 0.537 |
SH3TC1 | EMSY | ENSP00000245105 | ENSP00000433205 | SH3 domain and tetratricopeptide repeats 1. | BRCA2-interacting transcriptional repressor EMSY; Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may mediate ligand- dependent transcriptional activation by nuclear hormone receptors. | 0.428 |
SH3TC1 | GLT8D1 | ENSP00000245105 | ENSP00000266014 | SH3 domain and tetratricopeptide repeats 1. | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family. | 0.498 |
SH3TC1 | HCFC1R1 | ENSP00000245105 | ENSP00000248089 | SH3 domain and tetratricopeptide repeats 1. | Host cell factor C1 regulator 1; Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus. | 0.428 |
SH3TC1 | SORCS2 | ENSP00000245105 | ENSP00000422185 | SH3 domain and tetratricopeptide repeats 1. | VPS10 domain-containing receptor SorCS2; The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro). Plays a role in the regulation of dendritic spine density in hippocampus neurons (By similarity). Required for normal neurite branching and extension in response to BDNF. Plays a role in BDNF-dependent hippocampal synaptic plasticity. Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term poten [...] | 0.464 |
SH3TC1 | UNKL | ENSP00000245105 | ENSP00000301712 | SH3 domain and tetratricopeptide repeats 1. | Putative E3 ubiquitin-protein ligase UNKL; May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven. | 0.405 |
SORCS2 | ABLIM2 | ENSP00000422185 | ENSP00000393511 | VPS10 domain-containing receptor SorCS2; The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro). Plays a role in the regulation of dendritic spine density in hippocampus neurons (By similarity). Required for normal neurite branching and extension in response to BDNF. Plays a role in BDNF-dependent hippocampal synaptic plasticity. Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term poten [...] | Actin-binding LIM protein 2; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. | 0.455 |
SORCS2 | SH3TC1 | ENSP00000422185 | ENSP00000245105 | VPS10 domain-containing receptor SorCS2; The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro). Plays a role in the regulation of dendritic spine density in hippocampus neurons (By similarity). Required for normal neurite branching and extension in response to BDNF. Plays a role in BDNF-dependent hippocampal synaptic plasticity. Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term poten [...] | SH3 domain and tetratricopeptide repeats 1. | 0.464 |
UNKL | SH3TC1 | ENSP00000301712 | ENSP00000245105 | Putative E3 ubiquitin-protein ligase UNKL; May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven. | SH3 domain and tetratricopeptide repeats 1. | 0.405 |