node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTD | SLC19A2 | ENSP00000500193 | ENSP00000236137 | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | 0.619 |
BTD | SLC19A3 | ENSP00000500193 | ENSP00000495385 | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | Thiamine transporter 2; Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity. Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. | 0.732 |
LIPT1 | LIPT2 | ENSP00000377115 | ENSP00000309463 | Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes; Belongs to the LplA family. | Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes, which catalyze essential redox reactions. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity); Belongs to the LipB family. | 0.998 |
LIPT1 | SLC19A2 | ENSP00000377115 | ENSP00000236137 | Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes; Belongs to the LplA family. | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | 0.438 |
LIPT1 | SLC19A3 | ENSP00000377115 | ENSP00000495385 | Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes; Belongs to the LplA family. | Thiamine transporter 2; Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity. Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. | 0.518 |
LIPT1 | SLC25A19 | ENSP00000377115 | ENSP00000385312 | Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes; Belongs to the LplA family. | Mitochondrial thiamine pyrophosphate carrier; Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria. | 0.574 |
LIPT1 | TPK1 | ENSP00000377115 | ENSP00000353165 | Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes; Belongs to the LplA family. | Thiamin pyrophosphokinase 1; Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate. | 0.621 |
LIPT2 | LIPT1 | ENSP00000309463 | ENSP00000377115 | Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes, which catalyze essential redox reactions. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity); Belongs to the LipB family. | Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes; Belongs to the LplA family. | 0.998 |
LIPT2 | SLC19A2 | ENSP00000309463 | ENSP00000236137 | Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes, which catalyze essential redox reactions. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity); Belongs to the LipB family. | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | 0.489 |
LIPT2 | SLC19A3 | ENSP00000309463 | ENSP00000495385 | Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes, which catalyze essential redox reactions. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity); Belongs to the LipB family. | Thiamine transporter 2; Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity. Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. | 0.495 |
LIPT2 | SLC25A19 | ENSP00000309463 | ENSP00000385312 | Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes, which catalyze essential redox reactions. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity); Belongs to the LipB family. | Mitochondrial thiamine pyrophosphate carrier; Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria. | 0.497 |
LIPT2 | TPK1 | ENSP00000309463 | ENSP00000353165 | Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes, which catalyze essential redox reactions. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity); Belongs to the LipB family. | Thiamin pyrophosphokinase 1; Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate. | 0.562 |
SLC19A2 | BTD | ENSP00000236137 | ENSP00000500193 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. | 0.619 |
SLC19A2 | LIPT1 | ENSP00000236137 | ENSP00000377115 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes; Belongs to the LplA family. | 0.438 |
SLC19A2 | LIPT2 | ENSP00000236137 | ENSP00000309463 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes, which catalyze essential redox reactions. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity); Belongs to the LipB family. | 0.489 |
SLC19A2 | SLC19A3 | ENSP00000236137 | ENSP00000495385 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | Thiamine transporter 2; Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity. Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. | 0.909 |
SLC19A2 | SLC25A19 | ENSP00000236137 | ENSP00000385312 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | Mitochondrial thiamine pyrophosphate carrier; Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria. | 0.653 |
SLC19A2 | SLC46A1 | ENSP00000236137 | ENSP00000480703 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | Proton-coupled folate transporter; Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. Belongs to the major facilitator superfamily. SLC46A family. | 0.484 |
SLC19A2 | TKT | ENSP00000236137 | ENSP00000391481 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate; Belongs to the transketolase family. | 0.502 |
SLC19A2 | TKTL1 | ENSP00000236137 | ENSP00000358931 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine. | Transketolase-like protein 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate; Belongs to the transketolase family. | 0.519 |