node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C4orf3 | MRLN | ENSP00000382026 | ENSP00000488748 | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | Myoregulin; Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle. | 0.676 |
C4orf3 | SLN | ENSP00000382026 | ENSP00000435380 | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | Sarcolipin; Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle- based, non-shivering thermogenesis (By similarity). Belongs to the sarcolipin family. | 0.587 |
C4orf3 | SMIM6 | ENSP00000382026 | ENSP00000463361 | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | Small integral membrane protein 6. | 0.804 |
C4orf3 | STRIT1 | ENSP00000382026 | ENSP00000489859 | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF; Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity. Does not directly stimulate SERCA pump activity. Enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN). | 0.684 |
CDRT15L2 | SMIM6 | ENSP00000382000 | ENSP00000463361 | CMT1A duplicated region transcript 15 like 2. | Small integral membrane protein 6. | 0.520 |
CDRT15L2 | TBC1D28 | ENSP00000382000 | ENSP00000339973 | CMT1A duplicated region transcript 15 like 2. | TBC1 domain family member 28. | 0.621 |
CDRT15L2 | TBC1D3H | ENSP00000382000 | ENSP00000482630 | CMT1A duplicated region transcript 15 like 2. | TBC1 domain family member 3H; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). | 0.418 |
CDRT15L2 | TBC1D3K | ENSP00000382000 | ENSP00000484181 | CMT1A duplicated region transcript 15 like 2. | TBC1 domain family member 3K; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). | 0.506 |
MRLN | C4orf3 | ENSP00000488748 | ENSP00000382026 | Myoregulin; Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle. | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | 0.676 |
MRLN | SLN | ENSP00000488748 | ENSP00000435380 | Myoregulin; Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle. | Sarcolipin; Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle- based, non-shivering thermogenesis (By similarity). Belongs to the sarcolipin family. | 0.755 |
MRLN | SMIM6 | ENSP00000488748 | ENSP00000463361 | Myoregulin; Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle. | Small integral membrane protein 6. | 0.714 |
MRLN | STRIT1 | ENSP00000488748 | ENSP00000489859 | Myoregulin; Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle. | Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF; Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity. Does not directly stimulate SERCA pump activity. Enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN). | 0.871 |
SLN | C4orf3 | ENSP00000435380 | ENSP00000382026 | Sarcolipin; Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle- based, non-shivering thermogenesis (By similarity). Belongs to the sarcolipin family. | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | 0.587 |
SLN | MRLN | ENSP00000435380 | ENSP00000488748 | Sarcolipin; Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle- based, non-shivering thermogenesis (By similarity). Belongs to the sarcolipin family. | Myoregulin; Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle. | 0.755 |
SLN | SMIM6 | ENSP00000435380 | ENSP00000463361 | Sarcolipin; Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle- based, non-shivering thermogenesis (By similarity). Belongs to the sarcolipin family. | Small integral membrane protein 6. | 0.605 |
SLN | STRIT1 | ENSP00000435380 | ENSP00000489859 | Sarcolipin; Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle- based, non-shivering thermogenesis (By similarity). Belongs to the sarcolipin family. | Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF; Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity. Does not directly stimulate SERCA pump activity. Enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN). | 0.848 |
SMIM5 | SMIM6 | ENSP00000477017 | ENSP00000463361 | Small integral membrane protein 5. | Small integral membrane protein 6. | 0.459 |
SMIM6 | C4orf3 | ENSP00000463361 | ENSP00000382026 | Small integral membrane protein 6. | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3. | 0.804 |
SMIM6 | CDRT15L2 | ENSP00000463361 | ENSP00000382000 | Small integral membrane protein 6. | CMT1A duplicated region transcript 15 like 2. | 0.520 |
SMIM6 | MRLN | ENSP00000463361 | ENSP00000488748 | Small integral membrane protein 6. | Myoregulin; Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle. | 0.714 |