node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANTXR2 | SNX29 | ENSP00000306185 | ENSP00000456480 | Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix; Belongs to the ATR family. | Sorting nexin 29. | 0.451 |
AP2M1 | SNX29 | ENSP00000403362 | ENSP00000456480 | AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] | Sorting nexin 29. | 0.442 |
FAM43A | SNX29 | ENSP00000371397 | ENSP00000456480 | Protein FAM43A; Family with sequence similarity 43 member A; Belongs to the FAM43 family. | Sorting nexin 29. | 0.479 |
MSANTD1 | SNX29 | ENSP00000411584 | ENSP00000456480 | Myb/SANT-like DNA-binding domain-containing protein 1; Myb/SANT DNA binding domain containing 1. | Sorting nexin 29. | 0.478 |
SNX15 | SNX19 | ENSP00000366452 | ENSP00000265909 | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. | Sorting nexin-19; Plays a role in intracellular vesicle trafficking and exocytosis. May play a role in maintaining insulin- containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity). Belongs to the sorting nexin family. | 0.472 |
SNX15 | SNX20 | ENSP00000366452 | ENSP00000332062 | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. | Sorting nexin-20; May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion. | 0.419 |
SNX15 | SNX21 | ENSP00000366452 | ENSP00000418593 | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. | Sorting nexin-21; Binds to membranes enriched in phosphatidylinositol 3- phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking. Belongs to the sorting nexin family. | 0.416 |
SNX15 | SNX29 | ENSP00000366452 | ENSP00000456480 | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. | Sorting nexin 29. | 0.556 |
SNX19 | SNX15 | ENSP00000265909 | ENSP00000366452 | Sorting nexin-19; Plays a role in intracellular vesicle trafficking and exocytosis. May play a role in maintaining insulin- containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity). Belongs to the sorting nexin family. | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. | 0.472 |
SNX19 | SNX29 | ENSP00000265909 | ENSP00000456480 | Sorting nexin-19; Plays a role in intracellular vesicle trafficking and exocytosis. May play a role in maintaining insulin- containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity). Belongs to the sorting nexin family. | Sorting nexin 29. | 0.437 |
SNX20 | SNX15 | ENSP00000332062 | ENSP00000366452 | Sorting nexin-20; May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion. | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. | 0.419 |
SNX20 | SNX29 | ENSP00000332062 | ENSP00000456480 | Sorting nexin-20; May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion. | Sorting nexin 29. | 0.469 |
SNX21 | SNX15 | ENSP00000418593 | ENSP00000366452 | Sorting nexin-21; Binds to membranes enriched in phosphatidylinositol 3- phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking. Belongs to the sorting nexin family. | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. | 0.416 |
SNX21 | SNX29 | ENSP00000418593 | ENSP00000456480 | Sorting nexin-21; Binds to membranes enriched in phosphatidylinositol 3- phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking. Belongs to the sorting nexin family. | Sorting nexin 29. | 0.620 |
SNX29 | ANTXR2 | ENSP00000456480 | ENSP00000306185 | Sorting nexin 29. | Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix; Belongs to the ATR family. | 0.451 |
SNX29 | AP2M1 | ENSP00000456480 | ENSP00000403362 | Sorting nexin 29. | AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] | 0.442 |
SNX29 | FAM43A | ENSP00000456480 | ENSP00000371397 | Sorting nexin 29. | Protein FAM43A; Family with sequence similarity 43 member A; Belongs to the FAM43 family. | 0.479 |
SNX29 | MSANTD1 | ENSP00000456480 | ENSP00000411584 | Sorting nexin 29. | Myb/SANT-like DNA-binding domain-containing protein 1; Myb/SANT DNA binding domain containing 1. | 0.478 |
SNX29 | SNX15 | ENSP00000456480 | ENSP00000366452 | Sorting nexin 29. | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. | 0.556 |
SNX29 | SNX19 | ENSP00000456480 | ENSP00000265909 | Sorting nexin 29. | Sorting nexin-19; Plays a role in intracellular vesicle trafficking and exocytosis. May play a role in maintaining insulin- containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity). Belongs to the sorting nexin family. | 0.437 |