STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPANXCSperm protein associated with the nucleus on the X chromosome C; SPANX family member C; Belongs to the SPAN-X family. (97 aa)    
Predicted Functional Partners:
SPANXA1
Sperm protein associated with the nucleus, X-linked, family member A1.
   
  
0.999
SPANXB1
Sperm protein associated with the nucleus on the X chromosome B1; SPANX family member B1.
   
  
0.787
GAGE2A
G antigen 2A.
   
  
 0.618
GAGE2E
G antigen 2E.
   
  
 0.617
XAGE2
X antigen family member 2.
   
  
 0.572
MAGEC2
Melanoma-associated antigen C2; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.
   
  
 0.561
SSX1
Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family.
   
  
 0.551
GAGE1
G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family.
   
  
 0.543
GAGE12G
G antigen 12G.
   
  
 0.529
XAGE1A
X antigen family member 1A.
   
  
 0.510
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.