node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADH4 | PSG3 | ENSP00000424630 | ENSP00000332215 | All-trans-retinol dehydrogenase [NAD(+)] ADH4; Catalyzes the NAD-dependent oxidation of either all-trans- retinol or 9-cis-retinol. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Also catalyzes the reduction of benzoquinones. | Pregnancy specific beta-1-glycoprotein 3; Belongs to the immunoglobulin superfamily. CEA family. | 0.428 |
ADH4 | SPANXN3 | ENSP00000424630 | ENSP00000359534 | All-trans-retinol dehydrogenase [NAD(+)] ADH4; Catalyzes the NAD-dependent oxidation of either all-trans- retinol or 9-cis-retinol. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Also catalyzes the reduction of benzoquinones. | Sperm protein associated with the nucleus on the X chromosome N3; SPANX family member N3; Belongs to the SPAN-X family. | 0.525 |
ARIH1 | BTRC | ENSP00000369217 | ENSP00000359206 | E3 ubiquitin-protein ligase ARIH1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin- [...] | F-box/WD repeat-containing protein 1A; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradatio [...] | 0.556 |
ARIH1 | FBXW2 | ENSP00000369217 | ENSP00000476369 | E3 ubiquitin-protein ligase ARIH1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin- [...] | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | 0.585 |
ARIH1 | SPANXN3 | ENSP00000369217 | ENSP00000359534 | E3 ubiquitin-protein ligase ARIH1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin- [...] | Sperm protein associated with the nucleus on the X chromosome N3; SPANX family member N3; Belongs to the SPAN-X family. | 0.616 |
BTRC | ARIH1 | ENSP00000359206 | ENSP00000369217 | F-box/WD repeat-containing protein 1A; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradatio [...] | E3 ubiquitin-protein ligase ARIH1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin- [...] | 0.556 |
BTRC | FBXW2 | ENSP00000359206 | ENSP00000476369 | F-box/WD repeat-containing protein 1A; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradatio [...] | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | 0.736 |
BTRC | SPANXN3 | ENSP00000359206 | ENSP00000359534 | F-box/WD repeat-containing protein 1A; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradatio [...] | Sperm protein associated with the nucleus on the X chromosome N3; SPANX family member N3; Belongs to the SPAN-X family. | 0.590 |
CXorf40B | CXorf51A | ENSP00000359434 | ENSP00000489806 | Protein CXorf40B. | Uncharacterized protein CXorf51A; Chromosome X open reading frame 51A. | 0.646 |
CXorf40B | SPANXD | ENSP00000359434 | ENSP00000359546 | Protein CXorf40B. | Sperm protein associated with the nucleus on the X chromosome D; SPANX family member D; Belongs to the SPAN-X family. | 0.434 |
CXorf40B | SPANXN3 | ENSP00000359434 | ENSP00000359534 | Protein CXorf40B. | Sperm protein associated with the nucleus on the X chromosome N3; SPANX family member N3; Belongs to the SPAN-X family. | 0.570 |
CXorf51A | CXorf40B | ENSP00000489806 | ENSP00000359434 | Uncharacterized protein CXorf51A; Chromosome X open reading frame 51A. | Protein CXorf40B. | 0.646 |
CXorf51A | SPANXD | ENSP00000489806 | ENSP00000359546 | Uncharacterized protein CXorf51A; Chromosome X open reading frame 51A. | Sperm protein associated with the nucleus on the X chromosome D; SPANX family member D; Belongs to the SPAN-X family. | 0.431 |
CXorf51A | SPANXN3 | ENSP00000489806 | ENSP00000359534 | Uncharacterized protein CXorf51A; Chromosome X open reading frame 51A. | Sperm protein associated with the nucleus on the X chromosome N3; SPANX family member N3; Belongs to the SPAN-X family. | 0.545 |
FBXW2 | ARIH1 | ENSP00000476369 | ENSP00000369217 | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | E3 ubiquitin-protein ligase ARIH1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin- [...] | 0.585 |
FBXW2 | BTRC | ENSP00000476369 | ENSP00000359206 | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | F-box/WD repeat-containing protein 1A; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradatio [...] | 0.736 |
FBXW2 | SPANXN3 | ENSP00000476369 | ENSP00000359534 | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | Sperm protein associated with the nucleus on the X chromosome N3; SPANX family member N3; Belongs to the SPAN-X family. | 0.813 |
PSG3 | ADH4 | ENSP00000332215 | ENSP00000424630 | Pregnancy specific beta-1-glycoprotein 3; Belongs to the immunoglobulin superfamily. CEA family. | All-trans-retinol dehydrogenase [NAD(+)] ADH4; Catalyzes the NAD-dependent oxidation of either all-trans- retinol or 9-cis-retinol. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Also catalyzes the reduction of benzoquinones. | 0.428 |
PSG3 | SPANXN3 | ENSP00000332215 | ENSP00000359534 | Pregnancy specific beta-1-glycoprotein 3; Belongs to the immunoglobulin superfamily. CEA family. | Sperm protein associated with the nucleus on the X chromosome N3; SPANX family member N3; Belongs to the SPAN-X family. | 0.620 |
RIBC1 | SPANXN3 | ENSP00000364476 | ENSP00000359534 | RIB43A domain with coiled-coils 1; Belongs to the RIB43A family. | Sperm protein associated with the nucleus on the X chromosome N3; SPANX family member N3; Belongs to the SPAN-X family. | 0.455 |