STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TATDN2Putative deoxyribonuclease TATDN2; Putative deoxyribonuclease. (761 aa)    
Predicted Functional Partners:
XBP1
X-box-binding protein 1, cytoplasmic form; Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regio [...]
     
  0.750
CCDC174
Coiled-coil domain-containing protein 174; Probably involved in neuronal development.
 
 
  
 0.624
PRRT3
Proline rich transmembrane protein 3.
   
  
 0.579
MTFR1L
Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family.
      
 0.570
ADO
2-aminoethanethiol dioxygenase.
   
    0.533
ENSP00000481571
Uncharacterized protein.
      
 0.509
BAHD1
Bromo adjacent homology domain-containing 1 protein; Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3.
   
  
 0.508
IRAK2
Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
   
  
 0.492
VWA5B1
Von Willebrand factor A domain containing 5B1.
      
 0.483
UBE2L5
Ubiquitin-conjugating enzyme E2 L5; Catalyzes the covalent attachment of ubiquitin to other proteins.
      
 0.480
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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